Burkitt's Lymphoma


Burkitts lymphoma is a relatively rare and aggressive form of non-Hodgkins lymphoma. Non-Hodgkins lymphoma is a type of cancer of the lymphatic system. The lymphatic system helps your body to fight infections.

Burkitts lymphoma is most common in children living in sub-Saharan Africa, where it is related to the Epstein-Barr virus (EBV) and chronic malaria. Burkitts lymphoma is also seen elsewhere, including the U.S. Outside of Africa, Burkitts lymphoma is most likely to occur in people who have a compromised immune system.

What Causes Burkitts Lymphoma?

The exact cause of Burkitts lymphoma is not known. Risk factors vary according to geographic location. According to The Lancet, Burkitts lymphoma is the most common childhood cancer in regions where there is a high incidence of malaria, such as Africa. Elsewhere, the greatest risk factor is HIV/AIDS.

What Are the Types of Burkitts Lymphoma?

There are three types of Burkitts lymphoma: sporadic, endemic, and immunodeficiency-related. The types differ with by geographic location and the parts of the body that are affected.

Sporadic Burkitts Lymphoma

Sporadic Burkitts lymphoma occurs outside of Africa, but is rare in the developed world. It is sometimes associated with EBV. It tends to affect the lower abdomen, where the small intestine ends and the large intestine begins. .

Endemic Burkitts Lymphoma

This type of Burkitts lymphoma is most often seen in equatorial Africa, where it is associated with chronic malaria and EBV infection. The facial bone and jaw is most often affected. But the small intestine, kidneys, ovaries, and breast may also be involved.


This type of Burkitts lymphoma is associated with the use of immunosuppressive drugs such as those that used to prevent transplant rejection, and in the treatment of HIV/AIDS.

Who Is at Risk for Burkitts Lymphoma?

Burkitts lymphoma is most likely to affect children. It is rare in adults. The disease is more common in males and people with compromised immune systems, such as those with HIV/AIDS. The incidence is higher in North Africa, the Middle East, South America, and Papua New Guinea.

Sporadic and endemic forms are associated with EBV infection. Insect-borne viral infections and herbal extracts that promote tumor growth are possible contributing factors.

What Are the Symptoms of Burkitts Lymphoma?

Burkitts lymphoma can cause fever, weight loss, and night sweats. Other symptoms of Burktits lymphoma vary according to type.

Symptoms of Sporadic Burkitts Lymphoma

Symptoms of sporadic Burkitts lymphoma include:

  • abdominal pain and swelling (ascites)
  • involvement (including distortion) of facial bones
  • intestinal obstruction
  • enlarged thyroid
  • enlarged tonsils

Symptoms of Endemic Burkitts Lymphoma

Symptoms of endemic Burkitts lymphoma include:

  • swelling and distortion of facial bones
  • rapid increase in the size of lymph nodes (enlarged lymph nodes are non-tender)
  • tumors can grow extremely quickly, sometimes doubling their size within 18 hours

HIV-Related Lymphoma

Symtoms for HIV-related lymphoma are similar to those of the sporadic type.

How Is Burkitts Lymphoma Diagnosed?

A diagnosis of Burkitts lymphoma begins with a medical history and physical examination. A biopsy of tumors confirms the diagnosis. The bone marrow and central nervous system are often involved. Bone marrow and spinal fluid are usually examined to see how far the cancer has spread.

Burkitts lymphoma is staged according to lymph node and organ involvement. The involvement of bone marrow or the central nervous system means you have stage 4. A CT scan and MRI can help pinpoint which organs and lymph nodes are involved.

How Is Burkitts Lymphoma Treated?

Burkitts lymphoma is usually treated with combination chemotherapy. Chemotherapy agents used in the treatment of Burkitts lymphoma are:

  • cytarabine
  • cyclophosphamide
  • doxorubicin
  • vincristine
  • methotrexate
  • etoposide

Monoclonal antibody treatment with rituximab may be combined with chemotherapy.

Chemotherapy is injected directly into the spinal fluid (intrathecal) to prevent the cancer from spreading to the central nervous system. Patients who get intensive chemotherapy have the best treatment outcomes.

In developing nations, treatment is often less aggressive and less successful. Children with Burkitts lymphoma have the best prognosis. The presence of intestinal obstruction requires surgery.

What Is The Long-Term Outlook?

The outcome depends on the stage at diagnosis. It is often worse for adults over age 40, though treatment for adults has improved in recent years. The prognosis is poor in people who have HIV/AIDS. It is significantly better in people whose cancer has not spread.