Hyperimmunoglobulin E syndrome is a rare, inherited disease associated with abnormalities of the skin, sinuses, lungs, bones, and teeth.
Hyperimmunoglobulin E syndrome is also know as Job syndrome, after the biblical character Job whose faithfulness was tested by a lifelong affliction of draining skin sores and pustules. People with this condition have chronic and severe skin infections.
The symptoms are usually present in childhood, but because the disease is so rare, it often takes years before a correct diagnosis is made.
Recent research suggests that the disease is often caused by a genetic mutation (specifically, a change in the STAT3 gene on chromosome 4). How this gene abnormality causes the symptoms of the disease is not well understood, although it is known that people with the disease have higher-than-normal levels of an antibody called IgE.
An eye exam may reveal signs of dry eye syndrome. A physical exam may show signs of osteomyelitis, curving of the spine (kyphoscoliosis), and recurrent sinus infections.
A chest x-ray may reveal lung abscesses.
Tests used to confirm a diagnosis include:
Other tests that may be done:
There is no known cure for this condition. The goal of treatment is to control the recurrent infections. Medications include antibiotics. Antifungal and antiviral medications are prescribed when appropriate.
Sometimes, surgery is needed to drain abscesses.
Intravenous (IV, directly into a vein) gamma globulin may help build up the immune system temporarily when there are severe infections.
Job syndrome is a lifelong chronic condition. Each new infection requires treatment.
Call your health care provider if you are experiencing or observing a collection of the above signs and symptoms.
There is no proven prevention. Good general hygiene is helpful. Some doctors may recommend preventive antibiotics for people with many infections, particularly with Staphylococcus aureus. This does not change the underlying disorder but rather its consequences.
Job syndrome; Hyper IgE syndrome