Aloxi capsules and injection contain the active ingredient palonosetron hydrochloride, which is a type of medicine called a 5HT3 antagonist. Palonosetron is used to prevent nausea and vomiting caused by chemotherapy treatment for cancer.
Vomiting is controlled by an area of the brain called the vomiting centre. The vomiting centre is responsible for causing feelings of sickness (nausea) and for the vomiting reflex. It is activated when it receives nerve messages from another area of the brain called the chemoreceptor trigger zone (CTZ) and when it receives nerve messages from the gut.
Chemotherapy can cause a substance called serotonin (5HT) to be released in the gut. This 5HT acts on the 5HT3 receptors that are found in the gut and causes nerve messages to be sent to the vomiting centre.
5HT released by chemotherapy also activates the 5HT3 receptors that are found in the CTZ in the brain, causing further messages to be sent to the vomiting centre.
Palonosetron works by blocking the 5HT3 receptors that are found in the brain and gut. This prevents the nausea messages being sent from these areas to the vomiting centre. Palonosetron therefore prevents nausea, retching and vomiting that can otherwise be caused by chemotherapy treatment for cancer.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
This medicine is not known to interact significantly with any other medicines. However, you should always tell your doctor or pharmacist what medicines you are currently taking, including those bought without a prescription and herbal medicines, before you are given this medicine, so they can check that the combination is safe.
There may be an increased risk of an abnormal heart beat, seen on a heart monitoring trace (ECG) as a 'prolonged QT interval', if this medicine is used in combination with other medicines that can have this effect. These include the following:
There are currently no other medicines available in the UK that contain palonosetron as the active ingredient.