Anagrelide

Generic Name: Anagrelide (an-AG-re-lide)Brand Name: Agrylin

Anagrelide is used for:

Treating patients with high blood platelet levels (thrombocythemia) due to bone marrow problems. It may also be used for other conditions as determined by your doctor.

Anagrelide is a platelet-reducing agent. It works by decreasing the body's production of platelets, which helps to prevent blood clots.

Do NOT use Anagrelide if:

  • you are allergic to any ingredient in Anagrelide
  • you have severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Anagrelide :

Some medical conditions may interact with Anagrelide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart, liver, or kidney disease

Some MEDICINES MAY INTERACT with Anagrelide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Sucralfate because it may decrease Anagrelide 's effectiveness
  • Amrinone, aspirin, cilostazol, enoximone, milrinone, or olprinone because their actions and the risk of their side effects may be increased by Anagrelide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Anagrelide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Anagrelide :

Use Anagrelide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Anagrelide by mouth with or without food.
  • If you miss a dose of Anagrelide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anagrelide .

Important safety information:

  • Anagrelide may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anagrelide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Anagrelide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Anagrelide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Anagrelide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Anagrelide may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you are using Anagrelide before you have any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver function, kidney function, blood pressure, and blood counts, may be performed while you use Anagrelide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • If you may become pregnant, you must use an effective form of birth control while you take Anagrelide . If you have questions about effective birth control, talk with your doctor.
  • PREGNANCY and BREAST-FEEDING: Anagrelide may cause harm to the fetus. Avoid becoming pregnant while taking Anagrelide . If you think you may be pregnant, contact your doctor right away. It is not known if Anagrelide is found in breast milk. Do not breast feed while taking Anagrelide .

Possible side effects of Anagrelide :

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; cough; diarrhea; dizziness; drowsiness; gas; general body discomfort; headache; joint or muscle weakness; loss of appetite; nausea; stomach pain; tiredness; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine, stools, or vomit; changes in vision; chest pain, especially if sharp or crushing; depression; easy bruising or bleeding; fainting; fast or irregular heartbeat; flu-like symptoms (eg, sore throat, fever, or chills); memory loss; mental or mood changes; numbness or tingling of your skin or of an arm or leg; one-sided weakness; pounding in the chest; seizures; severe stomach pain; sudden leg pain; sudden severe headache, vomiting, dizziness, or fainting; shortness of breath; swelling of the hands, legs, or feet; trouble urinating.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include unusual bleeding and bruising.

Proper storage of Anagrelide :

Store Anagrelide at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anagrelide out of the reach of children and away from pets.

General information:

  • If you have any questions about Anagrelide , please talk with your doctor, pharmacist, or other health care provider.
  • Anagrelide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Anagrelide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Anagrelide Prescribing Information (FDA)
  • Anagrelide Professional Patient Advice (Wolters Kluwer)
  • anagrelide Advanced Consumer (Micromedex) - Includes Dosage Information
  • anagrelide Concise Consumer Information (Cerner Multum)
  • Agrylin Prescribing Information (FDA)