The name of your medicine is APO- Bisoprolol.
It contains the active ingredient bisoprolol fumarate.
It is used to treat heart failure. It is usually used in combination with other medicines.
Heart failure occurs when the heart muscle is weak and unable to pump enough blood to supply the body's needs. Heart failure may start off with no symptoms, but as the condition progresses patients may feel short of breath and notice swelling of the feet and ankles due to fluid build up.
Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
There is no evidence that this medicine is addictive.
Bisoprolol belongs to a group of medicines called beta-blockers.
These medicines work by affecting the body's response to some nerve impulses, especially in the heart. As a result, it decreases the heart's need for blood and oxygen and therefore reduces the amount of work the heart has to do.
Bisoprolol also slows your heart rate, which in turn increases the efficiency of your heart.
Bisoprolol can help to reduce the number of heart failure episodes needing hospital admission and also the risk of sudden death.
Bisoprolol is not recommended for use in children, as the safety and efficacy in children have not been established.
Do not take this medicine if you are hypersensitive to or have had an allergic reaction to bisoprolol or any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include cough, shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue, throat or other parts of the body; rash, itching or hives on the skin; fainting or hayfever-like symptoms.
If you think you are having an allergic reaction do not take any more of the medicine and contact your doctor immediately or go to the Accident and Emergency department at the nearest hospital.
Do not take bisoprolol if you have any of the following heart problems:
Do not take bisoprolol if you have any of the following medical conditions:
Before you start taking this medicine, tell your doctor if:
If you think any of these situations apply to you, or you have any doubts or questions about taking bisoprolol, consult your doctor or pharmacist.
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Taking bisoprolol may change the effect of some medicines, and some medicines may affect how well bisoprolol works. You may need different amounts of your medication or to take different medicines.
Do not take the following medicines with bisoprolol without special advice from your doctor:
However, do not stop taking these medicines without checking with your doctor.
Check with your doctor before taking the following medicines with bisoprolol:
Your doctor may need to check your condition more frequently.
Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking bisoprolol.
Follow carefully all directions given to you by your doctor or pharmacist. Their instructions may be different to the information in this leaflet.
The usual starting dose is 1.25 mg once daily for a week. If well tolerated, your doctor will gradually increase your dose over the next ten weeks. The usual dose for maintenance therapy is 10 mg once daily.
If your conditions gets worse or you no longer tolerate the drug, it may be necessary to reduce the dose again or to interrupt treatment. In some patients a maintenance dose lower than 10 mg may be sufficient. Your doctor will tell you what to do.
Your doctor will monitor your blood pressure, heart rate and other vital signs carefully after you start treatment with bisoprolol and during dose increase.
Follow all directions given to you by your doctor and pharmacist carefully.
Swallow your tablet(s) with a glass of water.
Do not crush or chew the tablets.
If you crush or chew the tablets, they will not work as well.
Take bisoprolol in the morning, with or without food.
To properly control your condition, bisoprolol must be taken every day, usually as a long term treatment.
Continue taking your medicine for as long as your doctor tells you.
It is very important that you do not stop taking bisoprolol suddenly.
Make sure you have enough to last over weekends and holidays.
If it is almost time for your next dose, skip the missed dose and take your next dose as usual.
Otherwise, take it as soon as you remember, and then go back to taking it as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively go to the Accident and Emergency Department at your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
Symptoms of an overdose may include slowed heart rate, difficulty breathing, marked drop in blood pressure, severe heart failure, or a decrease in blood sugar.
Tell your doctor that you are taking this medicine if:
Go to your doctor regularly for a check-up. Your doctor may check your eyes, thyroid, lipid and blood glucose levels.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Your doctor may think it is not working effectively and change your treatment unnecessarily.
Be careful driving or operating machinery until you know how bisoprolol affects you. Bisoprolol may cause tiredness, dizziness or light-headedness in some people, especially after the first dose. If any of these occur, do not drive, operate machinery or do anything else that could be dangerous.
Be careful getting up from a sitting or lying position.
Dizziness, light-headedness or fainting may occur, especially when you get up quickly. Getting up slowly may help.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking bisoprolol or if you have any questions or concerns.
Do not be alarmed by the following lists of side effects. You may not experience any of them.
Bisoprolol helps most people with heart failure, but it may have effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not.
Tell your doctor or pharmacist if you notice any of the following:.
Tell your doctor as soon as possible if you notice any of the following:
The above list includes serious side effects that may require medical attention.
Other side effects not listed above may occur in some patients.
Tell your doctor if you notice any other effects.
If you think you are having an allergic reaction to bisoprolol, do not take any more of this medicine and tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine in a cool dry place, away from light, where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking this medicine or they have passed their expiry date, your pharmacist can dispose of the remaining medicine safely.
1.25 mg: A white to off white, round, biconvex tablet, debossed '1.25' and plain on the other side
2.5 mg: A white to off white, round, biconvex tablet, debossed '2' bisect '5' and plain on the other side
3.75 mg: A white to off white, round, biconvex tablet, debossed '3.75' and plain on the other side
5 mg: A white to off white, round, biconvex tablet, debossed '5' on the left of a break line and plain on the other side
10 mg: A white to off white, round, biconvex tablet, debossed '10' on the left of a break line and plain on the other side
Each tablet contains 1.25 mg, 2.5 mg, 3.75 mg, 5 mg or 10 mg of bisoprolol fumarate as the active ingredient.
It also contains the following inactive ingredients:
This medicine is gluten-free, lactose-free, sucrose-free, tartrazine-free and free of other azo dyes.
APO-Bisoprolol 1.25 mg tablet (Blister pack): AUST R 182108.
APO-Bisoprolol 2.5 mg tablet (Blister pack): AUST R 182106.
APO-Bisoprolol 3.75 mg tablet (Blister pack): AUST R 182117.
APO-Bisoprolol 5 mg tablet (Blister pack): AUST R 182114.
APO-Bisoprolol 10 mg tablet (Blister pack): AUST R 182123.