The name of your medicine is APO-Candesartan HCTZ. It contains the active ingredients candesartan cilexetil and hydrochlorothiazide.
It is used to treat:
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
Candesartan cilexetil is a type of medicine called an angiotensin II receptor inhibitor (or antagonist). It mainly works by causing relaxation of blood vessels.
Hydrochlorothiazide is a type of medicine called a diuretic. It works by reducing the amount of excess fluid in the body.
Using these two medicines together will lower your blood pressure more effectively than using either one on its own.
There is no evidence that this medicine is addictive.
This medicine should not be used in children. The safety and effectiveness of this medicine in children under 18 years of age have not been established.
Do not use this medicine if:
Before you start taking this medicine, tell your doctor if:
1. You have allergies to:
2. You have or have had any medical conditions, especially the following:
3. You are currently pregnant or you plan to become pregnant. Do not take this medicine whilst pregnant.
4. You are currently breast-feeding or you plan to breast-feed. Do not take this medicine whilst breast-feeding.
5. You have recently been vaccinated or plan to get a vaccination.
6 You are planning to have surgery or an anaesthetic.
7 You are currently receiving or are planning to receive dental treatment.
8 You are taking or are planning to take any other medicines. This includes vitamins and supplements that are available from your pharmacy, supermarket or health food shop.
Some medicines and candesartan HCTZ may interfere with each other. These include:
These medicines may be affected by candesartan HCTZ or may affect the way it works. You may need different amounts of your medicines, or may need to take different medicines.
Other medicines not listed above may also interact with candesartan HCTZ.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.
Follow carefully all directions given to you by your doctor carefully.
Their instructions may be different to the information in this leaflet.
If you are not sure how to take this medicine, ask your doctor or pharmacist for help.
Your doctor or pharmacist will tell you how much of this medicine you should take. This will depend on your condition and whether you are taking any other medicines.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
The usual dose is one tablet once daily.
Swallow the tablets whole with a glass of water.
Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also help you remember when to take it.
It does not matter if you take it before, with or after food.
Continue taking this medicine for as long as your doctor tells you.
This medicine controls your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
Make sure you have enough to last over weekends and holidays.
If you forget to take a dose, take it as soon as you remember, as long as it is at least 12 hours before your next dose is due.
Then go back to taking it as you would normally.
If it is less than 12 hours to your next dose, skip the dose you missed and take your next dose when you are meant to.
Do not take a double dose to make up for missed doses. This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively go to the Accident and Emergency Department at your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
If you take too many candesartan HCTZ tablets, you may get a headache, feel sick (nausea), dizzy, thirsty and very tired.
Tell your doctor that you are taking this medicine if:
Your blood pressure will not be well controlled if you do not.
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Be careful driving or operating machinery until you know how candesartan HCTZ affects you.
You may feel dizzy when you start taking candesartan HCTZ due to the drop in your blood pressure.
Move slowly when getting out of bed or standing up if you feel faint, dizzy or light-headed.
Drink plenty of water while you are using this medicine, especially if you sweat a lot.
Please talk to your doctor or pharmacist about these possibilities if you think they may be a problem for you.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking this medicine or if you have any questions or concerns.
Do not be alarmed by the following lists of side effects. You may not experience any of them. All medicines can have side effects. Sometimes they are serious but most of the time they are not.
Tell your doctor if you notice any of the following and they worry you. Mostly, these are mild:
The following side effects have been reported very rarely by patients taking candesartan cilexetil: palpitations, agitation, anxiety, depression, trouble sleeping (insomnia), drowsiness (somnolence), nervousness, nightmare and sleep disorder. It is not known if these side effects are caused by candesartan cilexetil.
Tell your doctor as soon as possible if you notice any of the following:
The above list includes serious side effects and are usually rare. They may require medical attention.
If you experience any of the following, stop taking your medicine and contact your doctor immediately or go to Accident and Emergency at your nearest hospital:
These are very serious side effects and are usually very rare. You may need urgent medical attention or hospitalisation.
Other side effects not listed above may above may occur in some patients. Tell your doctor if you notice any other side effects.
If you think you are having an allergic reaction to candesartan HCTZ, do not take any more of this medicine and tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
Keep your tablets in the blister pack until it is time to take them.
If you take candesartan out of the blister pack it will not keep well.
Keep your tablets in a cool dry place where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking this medicine or it has passed its expiry date, your pharmacist can dispose of the remaining medicine safely.
APO-Candesartan HCTZ 16/12.5 mg tablets: light pink, oval, biconvex tablet with 'L3|02' on one side and a break line on the other side.
APO-Candesartan HCTZ 32/12.5 mg tablets: light yellow, oval, biconvex tablet with 'L3|04' on one side and a break line on the other side.
APO-Candesartan HCTZ 32/25 mg tablets: light pink, oval, biconvex tablet with 'L3|04' on one side and a break line on the other side.
APO-Candesartan HCTZ Tablets 16/12.5 mg contains 16 mg candesartan cilexetil and 12.5 mg of hydrochlorothiazide.
APO-Candesartan HCTZ Tablets 32/12.5 mg contains 32 mg candesartan cilexetil and 12.5 mg of hydrochlorothiazide.
APO-Candesartan HCTZ Tablets 32/25 mg contains 32 mg candesartan cilexetil and 25 mg of hydrochlorothiazide.
They also contain the following inactive ingredients:
This medicine is gluten-free, sucrose-free, tartrazine-free and free of other azo dyes.
APO-Candesartan is available in:
Blister packs of 7 and 30 tablets.
Not all strengths, and/or pack sizes may be available
APO-Candesartan 16/12.5 mg blister pack: AUST R 210565
APO-Candesartan 32/12.5 mg blister pack: AUST R 210566
APO-Candesartan 32/25 mg blister pack: AUST R 210567