The name of your medicine is APO-Donepezil. It contains the active ingredient donepezil (as donepezil hydrochloride).
It is used to treat mild, moderate and severe Alzheimer's disease, also called dementia of the Alzheimer's type.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
There is no evidence that this medicine is addictive.
This medicine belongs to a group of medicines called acetylcholinesterase inhibitors. They are thought to work by increasing the level of a chemical called acetylcholine in the brain.
Do not give this medicine to children.
There is not enough information to recommend using this medicine in children.
Do not use this medicine if:
Before you start taking this medicine, tell your doctor if:
1. You have allergies to:
2. You have or have had any medical conditions, especially the following:
3. You are currently pregnant or breastfeeding or you plan to become pregnant or breast-feed.
4. You are planning to have surgery or an anaesthetic.
5. You are currently receiving or are planning to receive dental treatment.
If you have not told your doctor about any of the above, tell them before you use this medicine.
Tell your doctor if you are taking any other medicines, including any that you buy at the chemist, supermarket or health food shop.
Some medicines and donepezil may interfere with each other. These include:
These medicines may be affected by donepezil or may affect the way donepezil works. You may need different amounts of your medicines, or may need to take different medicines.
Other medicines not listed above may also interact with donepezil.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.
Follow carefully all directions given to you by your doctor carefully.
Their instructions may be different to the information in this leaflet.
If you are not sure how to take this medicine, ask your doctor or pharmacist for help.
Your doctor or pharmacist will tell you how much of this medicine you should take. This will depend on your condition and whether you are taking any other medicines.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
Always swallow the tablets whole with a full glass of water.
Take the tablet every night just before you go to bed.
Taking it at the same time each day will have the best effect and will also help you remember when to take it.
It does not matter if you take it before, with or after food.
Continue taking this medicine for as long as your doctor tells you.
This medicine controls your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
It may take several weeks for donepezil to take effect, so do not be discouraged if you do not see an improvement straight away.
Make sure you have enough to last over weekends and holidays.
If it is almost time to take your next dose, skip the missed dose and take your next dose at the usual time.
Otherwise take it as soon as you remember and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of unwanted side effects.
If you forget to take it for more than one week, call your doctor before taking any more.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively go to the Accident and Emergency Department at your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
Symptoms of an overdose may include feeling sick in the stomach, vomiting, increased sweating or saliva production. You may also have a slow heartbeat, feel dizzy, have trouble breathing, faint, have fits, feel weak or not be able to control your bowel motions or passing of urine.
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
This medicine may cause fatigue, dizziness and muscle cramps especially at the start of treatment or when the dose is increased. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous.
In addition, Alzheimer's disease may affect your ability to drive or operate machinery. Ask your doctor whether it is safe for you to continue to drive or operate machinery.
Please talk to your doctor or pharmacist about any concerns you may have about the above.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are using this medicine.
Your doctor will decide whether any change in your treatment is needed.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following:
These are all mild side effects of donepezil.
Tell your doctor as soon as possible if you notice any of the following:
The above list includes serious side effects that may require medical attention. These side effects are rare.
If any of the following happen, tell your doctor immediately or go to Accident and Emergency at your nearest hospital.
The above list includes very serious side effects. You may need urgent medical attention or hospitalisation.
These side effects are very rare.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
Other side effects not listed above may above may occur in some people. Tell your doctor if you notice any other side effects.
If you think you are having an allergic reaction to donepezil, tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
Keep your tablets in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your tablets in a cool dry place where the temperature will stay below 30°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking this medicine or they have passed their expiry date, your pharmacist can dispose of the remaining medicine safely.
APO-Donepezil 5 mg tablet - white to off white, film coated round, biconvex tablet with 'APO' debossed on one side and 'DO' over '5' on the other.
APO-Donepezil 10 mg tablet - light yellow to yellow, film coated round, biconvex tablet with 'APO' debossed on one side and 'DO' over '10' on the other.
Each tablet contains 5mg or 10mg of donepezil (as donepezil hydrochloride) as the active ingredient.
It also contains the following inactive ingredients:
This medicine is gluten-free, sucrose-free, tartrazine-free and free of other azo dyes.
APO-Donepezil is available in:
Blister packs of 7, 14 and 28 tablets.
Bottles of 28, 100 and 500 tablets.
Not all strengths, pack types and/or pack sizes may be available
APO-Donepezil 5 mg tablet (blister pack): AUST R 168327
APO-Donepezil 5 mg tablet (bottle):
AUST R 168333
APO-Donepezil 10 mg tablet (bottle): AUST R 168331.
APO-Donepezil 10 mg tablet (blister pack): AUST R 168328