Apo-go injection contains the active ingredient apomorphine, which is a type of medicine called a dopamine agonist. It mimicks the activity of a substance in the brain called dopamine.
Dopamine is a substance known as a neurotransmitter. Neurotransmitters are found in the brain and nervous system and are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson's disease, and this is thought to be the cause of the disease symptoms.
Dopamine normally transmits messages by stimulating specific receptor sites in the brain. Apomorphine works by stimulating these same receptor sites. This produces the same effects as dopamine, and acts as a dopamine substitute. In this way apomorphine helps to restore the dopamine activity in the brain, which helps reduce the symptoms of Parkinson's disease.
Apomorphine is used to treat Parkinsonian symptoms that have not been controlled by levodopa and/or other dopamine agonists. It is only prescribed by specialists and the treatment must be started in hospital. The medicine is adminstered by injection under the skin (subcutaneously) of the lower abdomen or outer thigh. It must not be injected into a vein.
Apo-go is only suitable for people who can recognise the onset of their 'off' symptoms and be capable of injecting themselves, or who have a responsible carer able to inject the medicine for them when required. Several injections may be required per day, depending on the individual response. For people needing many injections, the medicine can be given as a continuous drip (subcutaneous infusion).
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.
There may be an increased risk of dizziness when moving from a lying or sitting position to sitting or standing (postural hypotension) if this medicine is used with other medicines that can have this effect, for example medicines to treat high blood pressure (antihypertensives). Your doctor may need to adjust the dose of your blood pressure medicine.
Antipsychotic medicines have an opposite action to this medicine, as they work by decreasing dopamine activity in the brain. They may therefore reduce the effect of apomorphine, or similarly, apomorphine may reduce their antipsychotic effect.
There are currently no other medicines available in the UK that contain apomorphine as the active ingredient.