The name of your medicine is APO- Morphine MR. It contains the active ingredient morphine sulfate (as pentahydrate)
It is used to treat:
Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
Opioid analgesics such as morphine sulphate have been used to treat chronic cancer pain for many years. In most cases addiction does not occur. However, over time your body becomes used to taking morphine, so if you suddenly stop taking your APOTEX-MORPHINE MR tablets you may experience some symptoms of withdrawal.
It is important that you discuss this issue with your doctor.
This medicine must not be used in children under one year of age or weighing less than 25 kg. Safety and effectiveness has not been established in children under one year of age or weighing less than 25kg.
Do not take this medicine if:
Morphine MR may affect your developing baby if you take it during pregnancy.
Like most medicines of this kind, Morphine MR is not recommended to be taken during pregnancy. Your doctor will discuss the risks and benefits of using it if you are pregnant.
Symptoms of an allergic reaction may include cough, shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue, throat or other parts of the body; rash, itching or hives on the skin; fainting or hayfever-like symptoms.
If you think you are having an allergic reaction do not take any more of the medicine and contact your doctor immediately or go to the Accident and Emergency department at the nearest hospital.
Before you start taking this medicine, tell your doctor if:
1. You have allergies to:
2. You have or have had any medical conditions, especially the following:
3. This medicine is not recommended to be taken during labour.
4. You are currently breast-feeding or you plan to breastfeed.
5. You are planning to have surgery or an anaesthetic.
6. You are currently receiving or are planning to receive dental treatment.
7. You are taking or are planning to take any other medicines. This includes vitamins and supplements that are available from your pharmacy, supermarket or health food shop.
Some medicines may interact with Morphine MR. These include:
If you are taking any of these you may need a different dose or you may need to take different medicines.
Other medicines not listed above may also interact with Morphine MR.
Follow carefully all directions given to you by your doctor or pharmacist. Their instructions may be different to the information in this leaflet.
Your doctor or pharmacist will tell you how much of this medicine you should take. This will depend on your condition and whether you are taking any other medicines.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
Morphine MR tablets must be swallowed whole.
Morphine MR tablets must not be chewed, crushed or dissolved.
Morphine MR tablets are only designed to work properly if swallowed whole. The tablets may release all their contents at once if broken, chewed. crushed or dissolved which can be dangerous and cause serious problems, such as an overdose or even death.
If you have trouble swallowing your tablets whole, talk to your doctor.
You must only take Morphine MR tablets by mouth.
Taking this medicine in a manner other than that prescribed by your doctor can be harmful to your health.
Morphine MR tablets should be taken every 12 hours. Morphine MR tablets must be taken regularly to control the pain. Taking Morphine MR tablets at regular time intervals means that the onset of pain is prevented.
It is important to take the tablets at the times you have been told to. If, however, you begin to experience pain and you are taking your Morphine MR as prescribed ('breakthrough pain'), contact your doctor as your dosage may have to be reviewed.
Continue taking your medicine for as long as your doctor tells you.
If you stop taking this medicine suddenly, your pain may worsen and you may experience withdrawal symptoms such as:
Make sure you have enough to last over weekends and holidays.
If you forget to take a dose, contact your doctor for advice.
Do not take a double dose to make up for missed doses.
This may increase the chance of you experiencing side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively go to the Accident and Emergency Department at your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
If someone takes an overdose they may become drowsy, tired, confused, lack muscle tone, have cold or clammy skin, have constricted pupils, have a very low blood pressure or slow heart rate, experience difficulties in breathing and possibly become unconscious or even die.
When seeking medical attention, take this leaflet and any remaining tablets with you to show the doctor. Also, tell them about any other medicines or alcohol which have been taken.
Tell your doctor that you are taking this medicine if:
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Over time your body may become used to you taking morphine so if you stop taking it suddenly, your pain may worsen and you may experience withdrawal symptoms. This is called physical dependence.
If you need to stop taking this medicine, your doctor will gradually reduce the amount you take each day, if possible, before stopping the medicine completely.
Be careful when driving or operating machinery until you know how this medicine affects you.
Ask your doctor's advice about whether or not it will be safe for you to drive or operate any machinery whilst taking Morphine MR.
You may feel drowsy when you begin to take Morphine MR tablets. If you drink alcohol, the drowsiness may be worse.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly.
Standing up slowly will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.
You may suffer from nausea or vomiting when taking Morphine MR tablets. If you vomit 2-3 hours after your dose your pain may come back as you will not have absorbed your morphine. If this happens speak to your doctor. Your doctor may prescribe some medicine to help stop you vomiting.
Constipation can be caused by morphine. You should speak to your doctor about your diet and the proper use of laxatives.
There is potential for abuse of morphine and the development of addiction to morphine. It is important that you discuss this issue with your doctor.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking APOTEX-MORPHINE MR tablets or if you have any questions or concerns.
Do not be alarmed by the following lists of side effects. You may not experience any of them. All medicines can have side effects. Sometimes they are serious but most of the time they are not.
Tell your doctor or pharmacist if you notice any of the following.
This list includes the more common side effects.
Other possible side effects are listed below. Tell your doctor or pharmacist as soon as possible if you notice any of the following:
Other side effects not listed above may occur in some patients.
If you think you are having an allergic reaction to APOTEX-MORPHINE MR tablets, do not take any more of this medicine and tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine in a cool dry place where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking this medicine or it has passed its expiry date, your pharmacist can dispose of the remaining medicine safely.
10 mg tablets
buff coloured, biconvex, smooth, round, film coated tablets with 10 on one face
30 mg tablets
violet coloured, biconvex, smooth, round, film coated tablets with 30 on one face
60 mg tablets
orange coloured, biconvex, smooth, round, film coated tablets with 60 on one face
100 mg tablets
grey coloured, biconvex, smooth, round, film coated tablets with 100 on one face
Available in blister packs of 20, 28 or 60 tablets.
* Not all strengths, pack types and/or pack sizes may be available.
Each tablet contains 10, 30, 60 or 100 mg of Morphine sulfate (as pentahydrate) as the active ingredient.
It also contains the following inactive ingredients:
The tablet coatings contain a different colourant for each strength, as follows:
Opadry buff OY-3607
Opadry violet OY-6708
Opadry orange OY-3533
Opadry grey OY-8238
This medicine is gluten-free, sucrose-free, tartrazine-free and free of other azo dyes. The 100 mg strength is lactose-free.
APOTEX-MORPHINE MR 10 mg tablets (blisters): AUST R 132251.
APOTEX-MORPHINE MR 30 mg tablets (blisters): AUST R 132254.
APOTEX-MORPHINE MR 60 mg tablets (blisters): AUST R 132256.
APOTEX-MORPHINE MR 100 mg tablets (blisters): AUST R 132258.