Artemether

Latest prescription information about Artemether and Lumefantrine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Generic Name : Artemether and Lumefantrine

Pronunciation : ar-TEM-e-ther- LOO-me-FAN-treen

Therapeutic Classification : Anti- Malarials

ICD Code : Y41.2

Trade Name(s): 
India- Abha-Lm, Adither Pl, Alither, Alither Forte, Anther, Arh-L, Arh-L Forte, Arlufe, Arsumet-L, Arte Plus, Artilum, Artivil Pl, Arumaria, A-Teem, Biofalcy-L, Coartrin, Combither, Duther, Epither , Falcimax P, Falcirid, Falcized-L, Falcydol, Go-Malra, Larither, Lphentin, Lumeart, Lumecap-A , Lumefal, Lumerax, Lumerax Syp, Lumether, Malatrit-E, Malither, Methicap, Nortee, Paluther, Rapither, R-Cure, Reonate-L, Rmther, Siothec-Lf, Sviz-Lf, Sviz-Lfd, Vixinate, Xeremal-Al, Zemal, Zemal Forte, Zemal Syr, Zensumet-L, Zuther.
International- Coartem.

Why it is prescribed (Indications) : 
This medication is an antimalarial agent, prescribed for malaria. 

When it is not to be taken (Contraindications): ♦It should not be co-administered with CYP3A4 inducers and patients with known hypersensitivity.

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: PO- A 3-day treatment schedule with a total of 6 doses is recommended for adult patients with a bodyweight of 35 kg and above: Four tablets as a single initial dose, 4 tablets again after 8 hours and then 4 tablets twice daily (morning and evening) for the following two days (total course of 24 tablets). patients weighing less than 35 kg, should follow pediatric dosage.
Pediatric: Po- A 3-day treatment schedule with a total of 6 doses is recommended: 5 kg to less than 15 kg bodyweight: One tablet as an initial dose, 1 tablet again after 8 hours and then 1 tablet twice daily (morning and evening) for the following two days (total course of 6 tablets).
15 kg to less than 25 kg bodyweight: Two tablets as an initial dose, 2 tablets again after 8 hours and then 2 tablets twice daily (morning and evening) for the following two days (total course of 12 tablets).
25 kg to less than 35 kg bodyweight: Three tablets as an initial dose, 3 tablets again after 8 hours and then 3 tablets twice daily (morning and evening) for the following two days (total course of 18 tablets).
35 kg bodyweight and above: Four tablets as a single initial dose, 4 tablets again after 8 hours and then 4 tablets twice daily (morning and evening) for the following two days (total course of 24 tablets).

How it should be taken : 
It comes as a tablet and capsule to take by mouth, with food.

Warnings and Precautions : 
* Caution needed for patients with history of heart, liver or kidney disease, mental illness, electrolyte imbalance, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* Avoid concomitant use of drugs known to prolong QT interval.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Do not eat grapefruit or drink grapefruit juice while taking this medication.

Side Effects : 
Central Nervous System - Dizziness, fatigue, headache, trouble in sleeping, tiredness and weakness.
Gastrointestinal - Diarrhea, loss of appetite, nausea, vomiting and stomach pain.
Miscellaneous - Cough, joint and muscle pain and stiffness.

Other Precautions : 
* Avoid excess dosage.

Storage Conditions : 
Store it at room temperature (25°C).