Aspirin, aloxiprin, caffeine (Askit powders)

How does it work?

This medicine contains three active ingredients, aspirin, aloxiprin and caffeine.Aspirin belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause pain, swelling and inflammation. Aspirin is therefore used to relieve pain and inflammation.Aloxiprin is an aspirin derivative that has similar actions to aspirin.Caffeine is a weak stimulant that is often included in painkilling preparations in small doses. It is claimed that the addition of caffeine may enhance the pain relieving effects of aspirin.

What is it used for?

  • Fever (pyrexia)
  • Mild to moderate pain, eg headache, rheumatic and muscular aches and pains, period pain, toothache, sore throat etc

Warning!

  • If symptoms persist despite treatment, seek medical advice from your doctor or pharmacist.
  • Children under 16 years of age should not take aspirin, unless on the advice of a doctor. This is because aspirin use in children has been associated with a rare condition called Reye's syndrome. This condition affects the brain and liver and though extremely rare, can be fatal. The causes of Reye's syndrome are not fully understood, but use of aspirin to treat fever in children with a virus has been implicated. There are many paracetamol and ibuprofen products not associated with Reye's syndrome available to treat pain and fever in this age group. For more advice talk to your pharmacist.
  • Do not exceed the recommended dose of this medicine, which will be stated in the product packaging or information leaflet supplied with the medicine.

Use with caution in

  • Asthma
  • Decreased kidney function
  • Decreased liver function
  • Dehydration
  • Elderly people
  • History of peptic ulcers

Not to be used in

  • Blood clotting disorder (haemophilia)
  • Breastfeeding
  • Children and adolescents under 16 years of age, unless on the advice of a doctor
  • Gout
  • People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema)
  • Peptic ulcer
  • Severely decreased kidney function
  • Severely decreased liver function

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine should be avoided in the third trimester of pregnancy, as it may affect the growth and development of the foetus or have harmful effects on foetal tissues. Seek medical advice from your doctor before using this medicine during any stage of pregnancy.
  • Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers as it may be harmful to the nursing infant. Seek medical advice from your doctor.

Label warnings

  • Dissolve or mix this medication with water before taking.
  • Take this medication with or after food.
  • This medication contains aspirin.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Nausea
  • Indigestion (dyspepsia)
  • Allergic reactions such as skin rash, swelling of the lips, tongue and throat (angioedema) or narrowing of the airways (bronchospasm)
  • Ulceration or bleeding of the stomach or intestines
  • Stomach or intestinal discomfort
  • Worsening of asthma

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

People taking anticoagulant medicines used to prevent the blood clotting, eg warfarin, should not take aspirin to relieve pain or inflammation. This is because aspirin can irritate the stomach lining, as well as increasing the effects of warfarin, both of which increase the likelihood of bleeding. There may be an increased risk of bleeding if aspirin is taken with other 'blood-thinning' (antiplatelet) medicines such as clopidogrel or ticlopidine.Aspirin reduces the rate at which the body can remove the medicine methotrexate. The two should not usually be used together. There is an increased risk of side effects if aspirin is taken with other non-steroidal anti-inflammatory drugs (NSAIDs), eg ibuprofen, diclofenac, indometacin. For this reason, aspirin should not be taken with any other NSAID. There may be an increased risk of bleeding or ulceration of the stomach or intestines if aspirin is taken with corticosteroids, eg prednisolone, dexamethasone.There may be an increased risk of side effects if aspirin is taken with acetazolamide.