Generic Name: aspirin, caffeine, and dihydrocodeine (AS pir in, KAF een, and dye HYE dro KOE deen)Brand Names: Synalgos-DC
Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.
Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
Dihydrocodeine is related to codeine. It is in a group of drugs called narcotic pain relievers.
The combination of aspirin, caffeine, and dihydrocodeine is used to treat moderate to severe pain.
Aspirin, caffeine, and dihydrocodeine may also be used for other purposes not listed in this medication guide.
a bleeding or blood clotting disorder; or
an allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.
Before taking aspirin, caffeine, and dihydrocodeine, tell your doctor if you have:
an enlarged prostate;
a thyroid disorder;
a history of head injury or brain tumor;
seizures or epilepsy;
Addison's disease; or
a history of drug or alcohol addiction.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.Dihydrocodeine may be habit-forming and should be used only by the person this medicine was prescribed for. This medication should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. FDA pregnancy category C. Aspirin may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. Dihydrocodeine could cause addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Do not take aspirin, caffeine, and dihydrocodeine without telling your doctor if you are pregnant or plan to become pregnant during treatment. Dihydrocodeine may also cause addiction and withdrawal symptoms in a nursing infant. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
Take this medication exactly as it was prescribed for you. Do not take it in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.Take with food or milk to ease stomach upset. You may have withdrawal symptoms when you stop using aspirin, caffeine, and dihydrocodeine after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using aspirin, caffeine, and dihydrocodeine. You may need to stop using the medicine for a short time.Store this medication at room temperature away from moisture and heat. Keep track of how many capsules have been used from each new bottle of this medicine. Dihydrocodeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Since aspirin, caffeine, and dihydrocodeine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
Overdose symptoms may include extreme drowsiness or insomnia, restless feeling, tremors, fast heart rate, pinpoint pupils, nausea, vomiting, dark urine, confusion, ringing in your ears, fainting, weak pulse, seizure (convulsions), blue lips, shallow breathing, or no breathing.
Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice.Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, antidepressants, or seizure medication can add to sleepiness caused by dihydrocodeine, or could slow your breathing. Tell your doctor if you need to use any of these other medicines while you are taking aspirin, caffeine, and dihydrocodeine.
shallow breathing, slow heart rate;
fast or pounding heart rate, muscle twitching;
confusion, unusual thoughts or behavior;
black, bloody, or tarry stools; or
coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
feeling dizzy, shaky, anxious, or agitated;
heartburn, mild nausea, vomiting, upset stomach, constipation, diarrhea;
itching or rash;
mood changes, sleep problems (insomnia);
sweating, urinating more than usual;
ringing in your ears; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking this medication, tell your doctor if you are using any of the following drugs:
a blood thinner such as warfarin (Coumadin); or
another salicylate such as choline salicylate and/or magnesium salicylate (Magan, Doan's, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal), or salsalate (Disalcid).
This list is not complete and there may be other drugs that can interact with aspirin, caffeine, and dihydrocodeine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.