Aylide together with diet and exercise, is used to lower high blood sugar levels in people with type 2 diabetes mellitus.
This type of diabetes is also known as non-insulin-dependent diabetes mellitus (NIDDM) or maturity onset diabetes.
Aylide is used when diet and exercise alone are not enough to control your condition. However, as Aylide does not replace these, your doctor will suggest that you continue with your diet and exercise programs, while you are taking Aylide.
Aylide contains the active ingredient glimepiride, which belongs to a group of medicines called sulfonylureas.
These medicines work to lower blood sugar levels by causing your pancreas to release more insulin into the blood stream.
Ask your doctor if you have any questions about why Aylide has been prescribed for you.
Your doctor may have prescribed Aylide for another reason.
Aylide is not recommended for use in children, as its safety and effectiveness in this age group has not been established.
Aylide is available only with a doctor's prescription.
There is no evidence that Aylide is addictive.
Do not take Aylide if you are allergic to:
Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; wheezing or shortness of breath.
Do not take Aylide if you have:
Do not take Aylide if you are pregnant or plan to become pregnant.
Aylide is not recommended for use during pregnancy. Your doctor will replace Aylide with insulin, as insulin is more suitable for controlling blood sugar during pregnancy.
Do not take Aylide if you are breastfeeding.
Aylide is not recommended for use during breastfeeding as it passes into breast milk and therefore may affect breastfed baby. Your doctor will advise you on what to do if you are breastfeeding.
Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Tell your doctor if you plan to become pregnant or breastfeed.
Tell your doctor if you have or have had any of the following medical conditions:
Your doctor may want to take special care if you have any of these conditions.
Tell your doctor if you:
Alcohol, diet, exercise, and your general health all strongly affect the control of your diabetes. Discuss these things with your doctor.
Tell your doctor if you plan to have surgery.
If you have not told your doctor about any of the above, tell him/her before you start taking Aylide.
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may be affected by Aylide, or may affect how well it works.
Some medicines may lead to low blood glucose (hypoglycaemia) by increasing the blood glucose-lowering effects of Aylide. These include:
Some medicines may lead to loss of control of your diabetes by weakening the blood glucose-lowering effect of Aylide. These include:
Aylide may change the effects of other medicines. These include:
Some medicines may hide the symptoms of low blood glucose (hypoglycaemia). These include:
If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Aylide.
Follow all directions given to you by your doctor and pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the pack, ask your doctor or pharmacist.
The dose varies from person to person.
The usual adult starting dose is 1 mg once a day. Your doctor may then increase this dose depending on how you respond to the medicine.
Aylide is not recommended for use in children.
People with kidney problems may need smaller doses.
Swallow the tablets whole with at least half a glass of water.
Aylide tablets can be divided in half along the breakline, if advised by your doctor or pharmacist.
You must make sure that you take Aylide just before or with a meal.
Aylide are usually taken once a day, immediately before breakfast. If you eat only a light breakfast, you should delay taking the tablet until after the first main meal of the day (e.g. lunch).
Do not skip meals while taking Aylide.
To properly control your condition, Aylide must be taken every day.
Keep taking Aylide for as long as your doctor tells you to.
Aylide is usually taken on a long-term basis. It is important to keep taking your medicine even if you feel well.
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take the missed dose as soon as you remember (with food) and then go back to taking your tablets as you would normally.
Missed doses can cause high blood sugar (hyperglycaemia).
Do not take a double dose to make up for the dose you missed.
If you double a dose, this may cause low blood sugar (hypoglycaemia).
If you are not sure what to do or have any questions, ask your doctor or pharmacist.
Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Aylide. Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Taking too much Aylide may cause severe hypoglycaemia or very low blood sugar levels. This is very serious and, if not treated quickly, can lead to loss of coordination, slurred speech, confusion, fitting, unconsciousness and coma.
At the first signs of hypoglycaemia, immediately raise your blood sugar levels by taking the following:
Unless you are within 10 to 15 minutes of your next meal, follow up with extra carbohydrates, e.g. plain biscuits, fruit or milk, when over the initial symptoms.
Taking this extra carbohydrate will prevent a second drop in your blood glucose level.
If not treated quickly, these symptoms may progress to loss of co-ordination, slurred speech, confusion, loss of consciousness and seizures.
Before starting any new medicine, tell your doctor or pharmacist that you are taking Aylide.
Tell all the doctors, dentists and pharmacists who are treating you that you are taking Aylide.
Keep a continuous supply so you don't run out, especially over weekends or during holidays.
If you become pregnant while taking Aylide, tell your doctor immediately.
If you plan to have surgery (that requires a general anaesthetic), including dental surgery, tell your doctor or dentist that you are taking Aylide.
Make sure you, your friends, family and work colleagues can recognise the symptoms of hyperglycaemia and hypoglycaemia and know how to treat them. Provide them with the telephone number for your doctor, the Poison information Centre (13 11 26 in Australia) and Emergency Services.
See "Controlling blood sugar".
Always carry some sugary food or drink with you.
If you experience any of the symptoms of low blood glucose (hypoglycaemia), immediately eat some sugary food or have a drink, e.g. lollies, biscuits or fruit juice. Diet and low calorie soft drinks do NOT contain sugar and are unsuitable to take for hypoglycaemia.
If you are elderly or are taking other medicines for diabetes, the risk of hypoglycaemia is increased.
The risk of hypoglycaemia is also increased in the following situations:
If you experience any signs of high blood sugar (hyperglycaemia), contact your doctor immediately.
The risk of hyperglycaemia is increased in the following:
Tell your doctor if you become ill, experience extra stress, have an injury, fever, infection, or need surgery.
Your blood sugar levels may become difficult to control during these times, and your doctor may decide to change your treatment to insulin.
Make sure you check your blood sugar levels regularly.
This is the best way to tell if your diabetes is being controlled properly. Your doctor, pharmacist or diabetes educator will show you how and when to do this.
Visit your doctor regularly so they can check on your progress.
Carefully follow your doctor's, and/or dietician's advice on diet, drinking alcohol and exercise.
Drinking alcohol while taking Aylide may increase your chances of getting hypoglycaemia.
You may get flushing, headache, breathing difficulties, rapid heart beat, stomach pains or feel sick and vomit. Your doctor may suggest you avoid alcohol while taking Aylide.
Tell your doctor immediately if you notice the return of any symptoms you had before starting Aylide.
These may include lethargy or tiredness, headache, thirst, passing large amounts of urine and blurred vision.
These may be signs that your treatment with Aylide may need to be reviewed.
Do not skip meals while taking Aylide.
Do not use Aylide to treat any other conditions unless your doctor tells you to.
Do not give this medicine to anyone else, even if they have the same condition, or if their symptoms seem similar to yours.
Protect your skin when you are in the sun, especially between 10am and 3pm.
Aylide may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight may cause a skin rash, itching, redness, or a severe sunburn.
If outdoors, wear protective clothing and use a 15+ sunscreen. If your skin does appear to be burning, tell your doctor immediately.
If you have to be alert, e.g. when driving, be especially careful not to let your blood glucose levels fall too low.
Low blood glucose levels may slow your reaction time and affect your ability to drive or operate machinery. Drinking alcohol can make this worse. However, Aylide by itself is unlikely to affect how you drive or operate machinery.
Make sure you know how you react to Aylide before you drive a car, operate machinery or do anything else that could be dangerous if you are dizzy or lightheaded. If this occurs, do not drive.
If you are travelling, it is a good idea to:
If you become sick with a cold, fever or flu, it is very important to continue taking Aylide, even if you feel unable to eat your normal meal. If you have trouble eating solid foods, use sugar-sweetened drinks as a carbohydrate substitute or eat small amounts of bland food.
Your diabetes educator or dietician can give you a list of food to use for sick days.
Your blood sugar levels may change if you:
If your blood sugar is not properly controlled, you may experience either:
These conditions can be very serious.
Make sure, you and your family and friends are aware of the signs and symptoms of hyperglycaemia and hypoglycaemia, and what to do.
Hyperglycaemia means high blood sugar levels. If it is not treated, it can lead to serious problems with your heart, eyes, circulation or kidneys. Signs of hyperglycaemia include:
Aylide is used to control this.
Hypoglycaemia means low blood sugar levels. If you are elderly, immobilised, drink alcohol or take more than one medicine for your diabetes, you may be more susceptible to hypoglycaemia.
Hypoglycaemia can be very serious and can occur suddenly.
Signs of hypoglycaemia include:
If hypoglycaemia is not treated promptly, these may progress to:
If you experience any of these symptoms, immediately take one of the following:
This helps to raise the sugar levels in your blood. Carry some of these with you in case of such as event.
Contact your doctor or go to Accident and Emergency at the nearest the hospital immediately if:
You may feel dizzy and shaky so do not drive.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Aylide.
Aylide is generally well tolerated.
However, like all other medicines, it may have unwanted side effects in some people.
Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
Tell your doctor immediately or go to Accident and Emergency at the nearest hospital if you notice any of the following:
The side effects listed above are serious and require urgent medical attention or hospitalisation.
Tell your doctor if you notice anything that is making you feel unwell.
This is not a complete list of all possible side effects.
Other side effects not listed above may also occur in some people, and some side effects (eg. changes in liver function) can only be found when your doctor does tests from time to time to check your progress.
Keep Aylide where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Keep your tablets in the pack until it is time to take them.
If you take the tablets out of the pack they will not keep well.
Keep your tablets in a cool dry place where the temperature stays below 25°C.
Do not store Aylide or any other medicine in the bathroom or near a sink.
Do not leave Aylide in the car or on window sills.
Heat and dampness can destroy some medicines.
If your doctor tells you to stop taking Aylide, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.
Aylide is available in 4 strengths:
Each pack contains 30 tablets.
The active ingredient in Aylide is glimepiride.
Each Aylide 1, 2, 3 and 4 tablet contains 1, 2, 3 or 4 mg of glimepiride, respectively.
The tablets also contain the following inactive ingredients:
The tablets do not contain sucrose, gluten, tartrazine or any other azo dyes (e.g. sunset yellow, allura red AC, brilliant scarlet).