Benefix injection contains the active ingredient nonacog alfa, which is a genetically engineered version of clotting factor IX. Factor IX is a protein that is essential for the process of blood clotting (coagulation). It is found in human plasma.
When bleeding occurs the body quickly seals the breaks in blood vessels by forming clots. A series of clotting proteins is involved in this process. Lack of any one of these clotting factors can lead to uncontrolled bleeding or excessive bruising following injury.
Factor IX is deficient from birth in people with haemophilia B. This deficiency causes the blood to clot very slowly and can result in prolonged bleeding following any injury or wound. People with haemophilia may also bleed spontaneously into muscles and joints.
Factor IX is given to people with haemophilia B to supplement their deficient factor IX. This is necessary to help the blood clot and stop bleeding following accidents, surgery or spontaneous bleeds. In severe cases it may also be given regularly every few days to prevent bleeding.
Nonacog alfa is a form of factor IX that is produced by recombinant DNA technology. It is a relatively newly developed medicine that has the advantage of not containing human proteins, unlike other factor IX products that are obtained from blood given by donors. This means that it does not carry a risk of contracting blood-borne viruses, such as HIV or hepatitis C.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
This medicine is not known to affect other medicines. However, before taking any other medicines or having other treatments it is important that you tell your pharmacist or the health professional that is treating you that you suffer from haemophilia B.
AlphaNine, Haemonine, Mononine and Replenine-VF are other brands of clotting factor IX that are prepared from plasma from screened blood donors.