Cabaser tablets contain the active ingredient cabergoline, which is a type of medicine called a dopamine agonist. (NB. Cabergoline is also available without a brand name, ie as the generic medicine.) Cabergoline works by mimicking the activity of a substance in the brain called dopamine.
Dopamine is a substance known as a neurotransmitter. Neurotransmitters are present in the brain and nervous system and are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson's disease, and this is thought to be the cause of the disease symptoms.
Dopamine normally transmits messages by stimulating specific receptor sites in the brain. Cabergoline works by stimulating these same receptor sites. This produces the same effects as dopamine, and acts as a dopamine substitute. In this way cabergoline helps to restore the dopamine activity in the brain, which helps reduce the symptoms of Parkinson's disease.
Cabergoline can be used by itself or in conjunction with levodopa to treat Parkinson's disease, and is particularly useful in people for whom levodopa alone is no longer providing adequate control of symptoms.
Cabergoline can cause a drop in blood pressure when you first start treatment, and this may cause dizziness or fainting. To minimise these side effects the dose of cabergoline is increased slowly, usually over three to four weeks. Follow the instructions given by your doctor or pharmacist.
(NB. Cabergoline is also used in lower doses to treat disorders that result from high levels of the hormone prolactin in the blood. The Cabaser brand of cabergoline is not licensed for these uses. See the Dostinex factsheet linked at the end of this article for more information about these other uses of cabergoline.)
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
This medicine is not recommended for use in combination with other ergot alkaloid derivatives, such as pergolide, bromocriptine, lisuride, ergotamine, dihydroergotamine or methysergide.
There may be an increased risk of a drop in blood pressure that makes you feel dizzy if this medicine is taken in combination with other medicines that can lower blood pressure, for example medicines to treat high blood pressure (antihypertensives). Tell your doctor if you feel dizzy after starting treatment with this medicine, as your doctor may need to adjust the dose of your blood pressure medicine.
This medicine should not normally be taken in combination with the following medicines, as these work by decreasing the activity of dopamine in the brain and so may oppose the effect of cabergoline:
Macrolide-type antibiotics such as erythromycin may possibly increase the concentration of cabergoline in the blood, which may increase the risk of its side effects. However, small amounts of erythromycin applied to the skin can be used safely.
Cabergoline tablets are also available without a brand name, ie as the generic medicine.