Klaricid XL tablets contain the active ingredient clarithromycin, which is a type of medicine known as a macrolide antibiotic. It is used to treat infections caused by bacteria.
Clarithromycin works by preventing bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. Clarithromycin doesnt directly kill the bacteria, but leaves them unable to increase in numbers. The remaining bacteria eventually die or are destroyed by the immune system. This treats the infection.
Clarithromycin is a broad-spectrum antibiotic that is active against a wide variety of bacteria that cause a wide variety of infections. Clarithromycin may be used to treat infections of the upper or lower airways, skin or soft tissue.
To make sure the bacteria causing an infection are susceptible to clarithromycin your doctor may take a tissue sample, for example a swab from the throat or skin, or a sputum sample.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Clarithromycin should not be taken by people who are taking any of the following medicines, because clarithromycin can raise the blood levels of these medicines, resulting in an increased risk of serious side effects:
Clarithromycin may reduce the breakdown of the medicines listed below. If the blood levels of these medicines are raised as a result, it may lead to an increased risk of their side effects. If you are taking one of these medicines and are prescribed clarithromycin you should let your doctor or pharmacist know if you experience any new or increased side effects:
Clarithromycin may also increase the blood levels and hence anti-blood-clotting effects of the anticoagulants nicoumalone and warfarin. As this may increase the risk of bleeding, people taking these combinations, particularly elderly people, may need more frequent monitoring of their blood clotting time (INR) so the dose of anticoagulant can be adjusted if necessary.
Clarithromycin may also increase the blood levels of cholesterol-lowering medicines called statins, eg atorvastatin and simvastatin. This may increase the risk of side effects on the muscles (myopathy) from these medicines. Combined use of simvastatin and clarithromycin should be avoided.
There may be an increased risk of abnormal heart beats if clarithromycin is taken in combination with any of the following medicines:
Oral typhoid vaccine (Vivotif) should not be taken until at least three days after you have finished a course of this antibiotic, because the antibiotic could make this vaccine less effective.
In the past, women using hormonal contraception such as the pill or patch would be advised to use an extra method of contraception (eg condoms) while taking an antibiotic like this one and for seven days after finishing the course. However, this advice has now changed. You no longer need to use an extra method of contraception with the pill, patch or vaginal ring while you take a course of antibiotics. This change in advice comes because to date there is no evidence to prove that antibiotics (other than rifampicin or rifabutin) affect these contraceptives. This is the latest guidance from the Faculty of Sexual & Reproductive Healthcare.
However, if you are taking the contraceptive pill and experience vomiting or diarrhoea as a result of taking this antibiotic, you should follow the instructions for vomiting and diarrhoea described in the leaflet provided with your pills.
Ritonavir may increase the blood level of clarithromycin. This is not normally a problem, but if you have kidney problems and are taking ritonavir your doctor should prescribe you an immediate-release form of clarithromycin, because a lower than normal dose of clarithromycin can be achieved this way.
Klaricid XL tablets have not been studied in combination with zidovudine. People taking zidovudine who need to take clarithromycin should be prescribed an immediate-release form of the antibiotic, such as those listed at the end of this factsheet.
Clarithromycin standard-release tablets, suspension and injection are also available without a brand name, ie as the generic medicine.