Daktarin oral gel (Miconazole)

How does it work?

Daktarin oral gel contains the active ingredient miconazole. Miconazole is an antifungal medicine used to treat infections with fungi and yeasts.

Miconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.

The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As miconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.

Miconazole also has some antibacterial action and kills certain bacteria that may also be present in the infection.

Daktarin oral gel is used to treat fungal infections of the mouth and throat, such as oral thrush. The gel should be held in the mouth for as long as possible before swallowing. For treating localised areas of infection in the mouth, a small amount of gel may be applied directly to the affected area with a clean finger. Daktarin oral gel can also be taken to treat fungal infections of the intestines.

What is it used for?

  • Prevention and treatment of fungal infections of the mouth, throat, stomach and intestines.
  • Daktarin oral gel can also be bought from pharmacies without a prescription, but only for treating and preventing fungal infections of the mouth and throat such as oral thrush.

Warning!

  • Daktarin oral gel should be taken after eating. When treating mouth and throat infections the gel should be held in the mouth for as long as possible before swallowing.
  • Daktarin oral gel is sticky. You should be careful to ensure that the gel doesn't obstruct the throat, as this may cause choking, particularly in children. The gel should not be put at the back of the throat, and the prescribed dose may be divided into smaller portions.
  • If you have false teeth (dentures) and are treating oral thrush you should brush the gel onto your dentures after you take them out at night to kill any fungus that may be on the dentures.
  • Treatment with this medicine should be continued for two days after the symptoms have cleared up to ensure the infection is fully treated and thus help prevent it coming back.

Not to be used in

  • Infants under four months of age, or those whose swallowing reflex is not yet fully developed.
  • Decreased liver function.
  • Hereditary blood disorders called porphyrias.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine is not recommended for use during pregnancy unless considered essential by your doctor. It should only be used if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.
  • It is not known if this medicine passes into breast milk. It should be used with caution in nursing mothers, and only if the benefits to the mother outweigh any risks to the nursing infant. Discuss this with your doctor.

Label warnings

  • Take at regular intervals. Complete the prescribed course unless otherwise directed.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Nausea.
  • Vomiting.
  • Diarrhoea.
  • Allergic reactions.
  • Inflammation of the liver (hepatitis).

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

This medicine should not be taken by people who are taking any of the following medicines:

  • astemizole
  • cisapride
  • ergot alkaloids, eg ergotamine, methysergide
  • midazolam taken by mouth
  • mizolastine
  • pimozide
  • quinidine
  • sertindole
  • statins for lowering cholesterol, eg simvastatin and lovastatin
  • terfenadine
  • triazolam.

This medicine increases the anti-blood-clotting effect of anticoagulant medicines such as warfarin, nicoumalone and phenindione, which may increase the risk of bleeding. If you are taking an anticoagulant your doctor may want to monitor your blood clotting time (prothrombin time or INR) during and after a course of this medicine, and may need to alter the dose of your anticoagulant as a result.

Miconazole may increase the blood levels of the following medicines. As this could increase the risk of side effects, your doctor may need to reduce the dose of these medicines if you are taking them in combination with miconazole:

  • benzodiazepines such as alprazolam
  • buspirone
  • busulfan
  • calcium channel blockers such as felodipine, nifedipine
  • carbamazepine
  • ciclosporin
  • cilostazol
  • phenytoin
  • protease inhibitors for HIV infection, eg saquinavir
  • reboxetine
  • rifabutin
  • sirolimus
  • sulphonylureas used for diabetes, eg glibenclamide, gliclazide and tolbutamide (the blood sugar lowering effect of these medicines may be enhanced, which may cause hypoglycaemia)
  • tacrolimus.

Other medicines containing the same active ingredient

Daktarin Aktiv Daktarin cream Daktarin powder
Gyno-DaktarinLoramyc