Neoclarityn tablets and oral solution contain the active ingredient desloratadine, which is a type of medicine called a non-sedating antihistamine. It works by preventing the actions of histamine.
Histamine is a substance produced by the body as part of its defence mechanisms. It is stored in cells called mast cells, in almost all tissues of the body. When the body reacts to a foreign substance (known as an allergen, eg flower pollen, dust mites), the mast cells stimulated by the allergen release their stores of histamine.
The released histamine then binds to its receptors (H1 receptors), causing a chain reaction that results in allergic symptoms. It causes an increase in blood flow to the area of the allergy, and the release of other chemicals that add to the allergic response.
All this results in the symptoms of an allergic reaction. In hay fever and other nasal allergies (allergic rhinitis), histamine causes inflammation of the nose, eyes, skin or airways and results in itchy watery eyes, a runny nose, sneezing and nasal congestion. In skin allergies, histamine causes inflammation of the skin and results in an itchy rash, swelling and hives, called nettle rash or urticaria.
Desloratadine works by blocking histamine receptors. It doesn't prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever and nettle rash.
Desloratadine is called a non-sedating antihistamine as it doesn't enter the brain and is therefore unlikely to cause drowsiness. However, people react differently to medicines and some people may experience some drowsiness.
Neoclarityn tablets may be used for adults and adolescents aged 12 years and over.
Neoclarityn oral solution may be used for adults, adolescents and children aged one year and over.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
No significant interactions have been reported with this medicine. However, you should always tell your doctor or pharmacist if you are already taking any medicines, including over-the-counter medicines and herbal medicines, before you start taking this one. Likewise, it is important to check with your doctor or pharmacist before taking any new medicines once you have started this one, so they can make sure that the combination is safe.
Antihistamines may oppose the effect of histamine (used to treat leukaemia) and are not recommended for people having this treatment.
Antihistamines may also oppose the effect of betahistine (used to treat Ménière's disease).
Desloratadine tablets are also available without a brand name, ie as the generic medicine.