Desmospray contains the active ingredient desmopressin, which is a type of medicine called a vasopressin analogue. It is similar to a hormone produced naturally by the body, called vasopressin or antidiuretic hormone. (NB. Desmopressin nasal spray is also available without a brand name, ie as the generic medicine.)
Antidiuretic hormone (ADH) is produced by the pituitary gland in the brain. It is involved in controlling the natural balance of water levels in the body. It normally acts on receptors in the kidneys to prevent excessive amounts of water being filtered out of the blood and into the urine. This reduces the production of urine. Desmopressin is similar in structure to this hormone and works by mimicking its action.
In the condition diabetes insipidus, the kidneys produce excessive quantities of very dilute (but otherwise normal) urine. This causes excessive thirst and can lead to dehydration. Diabetes insipidus can be caused by a problem with the kidneys themselves (nephrogenic diabetes insipidus), or by a deficiency in the production of ADH by the pituitary gland (cranial diabetes insipidus). Desmopressin is used to diagnose and treat this latter rare form of diabetes (which should not be confused with diabetes mellitus, also known as sugar diabetes).
Desmopressin works by binding to the ADH receptors in the kidneys, which mimics the effect of natural ADH. This reduces the production of urine.
Desmopressin can also be used to prevent excessive urination at night (nocturia) in people with multiple sclerosis. It is used when other treatments for this have been unsuccessful.
Desmospray is a nasal spray that is administered into the nose. The desmopressin is absorbed into the bloodstream from the rich supply of blood vessels lining the nasal passages. Follow the instructions for use that are provided with the spray.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.
The following medicines may increase the release of natural antidiuretic hormone in the body and may therefore increase the effect of desmopressin:
If you are taking desmopressin with any of these medicines you should carefully follow instructions about restricting your fluid intake, because these medicines may increase the risk of fluid retention and decreased concentration of sodium in the blood. Your doctor may want to monitor the level of sodium in your blood more frequently.
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Desmopressin nasal spray (10 micrograms per spray) is also available without a brand name, ie as the generic medicine.