Trade Names:Aggrenox- Capsules 200 mg dipyridamole, extended-release/25 mg aspirin
Antithrombotic action resulting from additive antiplatelet effects.
Reduce the risk of stroke in patients who have had transient ischemia of the brain or complete ischemic stroke caused by thrombosis.
Hypersensitivity to dipyridamole, aspirin, or other components of product; allergy to NSAIDs; patients with asthma, rhinitis, and nasal polyps; children or teenagers with viral infections, with or without fever (Reye syndrome).
PO 1 capsule (200 mg extended-release dipyridamole/25 mg aspirin) twice daily, 1 in morning and 1 in evening with a full glass of water. Do not crush or chew.
Store at controlled room temperature. Protect from excessive moisture.
Metabolism of adenosine may be inhibited by dipyridamole, producing profound bradycardia.Cholinesterase inhibitors (eg, tacrine)
Dipyridamole may counteract anticholinesterase effect, potentially aggravating myasthenia gravis.ACE inhibitors (eg, captopril), beta blockers (eg, propranolol), diuretics (eg, furosemide), uricosuric agents (eg, probenecid)
The effects of these agents may be decreased by aspirin.Acetazolamide, anticoagulants (eg, warfarin), anticonvulsants (eg, valproic acid), methotrexate, NSAIDs (eg, ibuprofen), oral hypoglycemic agents (eg, chlorpropamide)
The pharmacologic and toxic effects of these agents may be increased by aspirin.
None well documented.
Cardiac failure; arrhythmia; supraventricular tachycardia.
Headache; amnesia; convulsions; anorexia; somnolence; confusion; coma; cerebral, subarachnoid, and intracranial hemorrhage.
Abdominal pain; dyspepsia; nausea; vomiting; diarrhea; melena; rectal hemorrhage; GI hemorrhage; hemorrhoids; perforation; Reye syndrome.
Hemorrhage; epistaxis; anemia; purpura.
Coughing; upper respiratory infection.
Arthralgia; arthritis; myalgia; arthrosis; pain; fatigue; back pain; asthenia; neoplasm; malaise; syncope; anaphylaxis; laryngeal edema; rhabdomyolysis.
Monitor patient for signs and symptoms of cerebral ischemia.
Category D (aspirin); Category B (dipyridamole).
Excreted in breast milk.
Safety and efficacy not established.
Avoid in patients with severe renal failure (ie, glomerular filtration rate less than 10 mL/min).
Concurrent consumption of alcohol may increase risk of bleeding.
Platelet function may be inhibited, increasing the risk of bleeding.
Use with caution.
Use with caution.
Dipyridamole: warm feeling, flushes, sweating, restlessness, weakness, dizziness, hypotension, tachycardia. Aspirin: tinnitus, nausea, vomiting, dizziness, respiratory alkalosis, metabolic acidosis, hemorrhage, convulsions. Significant overdose (4 to 10 g aspirin) is a medical emergency.
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