Emend Intravenous

Generic Name: fosaprepitant (Intravenous route)

fos-ap-RE-pi-tant

Commonly used brand name(s):

In the U.S.

  • Emend

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Neurokinin-1 Receptor Antagonist

Uses For Emend

Fosaprepitant is used with other medicines to prevent nausea and vomiting that may occur during cancer treatment (chemotherapy) .

This medicine is available only with your doctor's prescription .

Before Using Emend

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of fosaprepitant in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of fosaprepitant in the elderly .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Astemizole
  • Cisapride
  • Pimozide
  • Terfenadine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Etoposide
  • Ifosfamide
  • Imatinib
  • Irinotecan
  • Paclitaxel
  • Vinblastine
  • Vincristine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alprazolam
  • Dexamethasone
  • Diltiazem
  • Estradiol Cypionate
  • Ethinyl Estradiol
  • Etonogestrel
  • Ketoconazole
  • Levonorgestrel
  • Medroxyprogesterone
  • Mestranol
  • Midazolam
  • Norethindrone
  • Norgestrel
  • Rifampin
  • Tolbutamide
  • Triazolam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, severe—This medicine has not been studied in patients with this condition .

Proper Use of Emend

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins .

This medicine is usually given on the first day of your chemotherapy as part of a three-day regimen along with other medicines. Fosaprepitant is not for long-term use, but you may need to use this medicine again if you have more chemotherapy in the future .

This medicine is not usually used to treat nausea or vomiting that has already started .

You may receive this medicine with or without food .

Precautions While Using Emend

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects .

You should not receive this medicine if you are also using pimozide (e.g., Orap®), terfenadine (e.g., Seldane®), astemizole (e.g., Hismanal®), or cisapride (e.g., Propulsid®). Fosaprepitant may cause serious or life-threatening problems if used together with these medicines .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements .

Birth control pills may not work while you are using fosaprepitant. To keep from getting pregnant, use another form of birth control along with your birth control pills. Other forms include condoms, a diaphragm, or a contraceptive foam or jelly .

Emend Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Black, tarry stools
  • chills
  • confusion
  • cough
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • fever
  • increase in heart rate
  • lightheadedness
  • lower back or side pain
  • pain at injection site
  • painful or difficult urination
  • pale skin
  • rapid breathing
  • shortness of breath
  • sore throat
  • sunken eyes
  • thirst
  • ulcers, sores, or white spots in mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wrinkled skin
Less common
  • Hard lump at injection site

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
  • Drowsiness
  • headache
  • tenderness, swelling, warmth, or skin discoloration at injection site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • diarrhea
  • dizziness
  • feeling of indigestion
  • hair loss, thinning of hair
  • hiccups
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • nausea
  • pain in the chest below the breastbone
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • weight loss
Less common
  • Feeling of warmth
  • pain or discomfort in chest, upper stomach, or throat
  • redness of the face, neck, arms and occasionally, upper chest
  • sudden sweating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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