Estradiol (Systemic)

(es tra DYE ole)

Brand Names: U.S.

  • Alora
  • Climara
  • Delestrogen
  • Depo-Estradiol
  • Divigel
  • Elestrin
  • Estrace
  • Estrasorb
  • Estrogel
  • Evamist
  • Femring
  • Femtrace [DSC]
  • Menostar
  • Minivelle
  • Vivelle-Dot

Brand Names: Canada

  • Climara®
  • Depo®-Estradiol
  • Estraderm®
  • Estradot®
  • EstroGel®
  • Menostar®
  • Oesclim®
  • Sandoz-Estradiol Derm 100
  • Sandoz-Estradiol Derm 50
  • Sandoz-Estradiol Derm 75

What key warnings do I need to know about before giving this drug to my child?

  • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
  • Sometimes drugs are not safe when your child takes them with other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your child’s doctor about all the drugs your child takes.

Is it safe for my child to take this drug?

  • Not if your child has an allergy to estradiol or any other part of this drug.
  • Be sure to let the doctor know if your child has any allergies or side effects to drugs, foods, or dyes. Make sure to tell about the allergy and what signs your child had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • Not if your child has any of these health problems: Liver disease or vaginal bleeding.

Why does my child need this drug?

  • It is used when the ovaries have been taken out, are not working the right way, or have stopped working.

How is this drug given?

  • Shot:
  • It is given as a shot into a muscle.
  • Oral:
  • Give this drug at the same time of day.
  • Give this drug with food.
  • There may be days when your child will not take this drug.
  • Skin patch:
  • Put patch on clean, dry, healthy skin on the chest, back, or belly. Move the site with each new patch.
  • Do not place on breast.
  • If the patch falls off, put a new one on.

How long does this drug take to work?

  • It starts working as soon as it is given.

What do I do if my child misses a dose?

  • Oral:
  • Give a missed dose as soon as you think about it.
  • If it is close to the time for your child's next dose, skip the missed dose and go back to your child's normal time.
  • Do not give 2 doses or extra doses.
  • Do not change the dose or stop your child's drug. Talk with your child's doctor.
  • Skin patch:
  • Put on a missed patch as soon as you think about it after taking off the old one.
  • Start a new timetable after the patch is put back on.
  • Do not put on 2 doses or extra doses.
  • Do not change the dose or stop this drug. Talk with the doctor.

What safety measures do I need to take when my child is using this drug?

  • Keep a list of all your child's drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child's doctor.
  • If your child is allergic to tartrazine, talk with your child's doctor. Some products have tartrazine.
  • If your child has asthma, talk with the doctor.
  • If your child has any blood flow problems, talk with the doctor.
  • If your child has high blood sugar (diabetes), talk with the doctor.
  • If your child has gallbladder disease, talk with the doctor.
  • If your child has heart disease, talk with the doctor.
  • If your child has had high calcium levels, talk with the doctor.
  • If your child has high cholesterol or triglyceride levels, talk with the doctor.
  • If your child has kidney disease, talk with the doctor.
  • If your child has migraine headaches, talk with the doctor.
  • If your child has seizures, talk with the doctor.
  • Check all drugs your child is taking with your child's doctor. This drug may not mix well with some other drugs.
  • If your child is taking a blood thinner, have his/her blood work checked. Talk with your child's doctor.
  • Your child may get sunburned more easily. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and dress your child in clothing and eyewear that protects him/her from the sun.
  • Skin patch:
  • The patch may have metal. Take off your child's patch before an MRI.

What are some side effects of this drug?

  • Headache.
  • Belly pain.
  • Upset stomach or throwing up. Many small meals and good mouth care may help. Older children may suck hard, sugar-free candy.
  • Swelling.
  • Skin irritation.
  • Enlarged breasts.

When do I need to call my child's doctor?

  • If any of this news causes you to be worried, any of the unwanted side effects happen, or if your child is not better after taking this drug.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
  • If your child shows signs of a very bad reaction, call your child's doctor or the ER right away. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; swelling of face, lips, tongue, or throat; or if your child is not acting normal.
  • If your child has a very bad upset stomach or is throwing up.
  • If your child has chest pain or pressure.
  • If your child has trouble breathing.
  • If your child has swelling or pain in his/her leg or arm.
  • If your child has a bad headache.
  • If your child is not able to eat.
  • If your child has very bad skin irritation.
  • If your child has any bruising or bleeding.
  • If your child has dark urine or yellow skin or eyes.
  • If your child gets a rash.
  • If your child’s health problem does not get better or if you believe your child’s health problem is worse.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • The shot will be given to your child in a hospital or doctor's office. You will not store it at home.

General drug facts

  • If your child has a very bad allergy, he/she needs to wear an allergy ID at all times.
  • You may get this drug by drug order only. If there are refills, call your pharmacy. If your child does not have refills left, you may need to call your child's doctor.
  • Get rid of this drug when your child no longer needs it or if the drug is outdated.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
  • Do not share your child's drug with others and do not give anyone else's drug to your child.
  • Keep all drugs out of the reach of children and pets.
  • Keep a list of all your child's drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child's doctor.
  • These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
  • Talk with the doctor before giving your child any new drug, including OTC, natural products, or vitamins.
  • If you do not use a drug the right way, it may not be safe. Follow what your child’s doctor tells you.