Eudemine tablets (Diazoxide)

How does it work?

Eudemine tablets contain the active ingredient diazoxide, which is a type of medicine called a thiazide. It is used to treat long-term low blood sugar levels (hypoglycaemia) that are a result of excessive production of insulin by the pancreas.

Insulin is the main hormone responsible for the control of sugar in the blood. It is released from cells in the pancreas in response to high levels of sugar in the blood and causes a reduction in blood sugar levels. If too much insulin is produced by the cells in the pancreas, for example due to a tumour, this can cause blood sugar levels too fall too low and stay too low (hypoglycaemia).

Diazoxide works by slowing down the release of insulin from the pancreas. This helps blood sugar levels to increase.

What is it used for?

  • Long-term low blood sugar levels (hypoglycaemia) due to excessive production of insulin by the pancreas.

How do I take it?

  • Eudemine tablets can be taken with or without food. The tablets should be swallowed with a drink of water.
  • The dose prescribed and how often the medicine needs to be taken will depend on your blood sugar levels. The tablets are usually taken two or three times a day.


  • Your blood pressure should be monitored regularly while you are taking this medicine. If you feel dizzy or faint while taking this medicine you should lie down until the symptoms pass.
  • People taking this medicine for prolonged periods of time should have regular blood tests to check the levels of their blood cells. Tell your doctor if you experience any unexplained bruising or bleeding, sore throat or fever while taking this medicine, as these could be signs of a problem with your blood cells.
  • Regular growth, bone and developmental checks must be carried out in children taking this medicine.
  • Diazoxide may cause your body to retain water and you may need to take diuretic tablets (also known as 'water tablets') to help you get rid of this excess fluid.

Use with caution in

  • Heart disease.
  • Decreased kidney function.
  • People with a high level of uric acid in their blood (hyperuricaemia).
  • People with a history of gout.
  • People with a lower than usual number of proteins in their blood (plasma proteins).

Not to be used in

  • Allergy to thiazide diuretics such as bendroflumethiazide.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine should not be used during pregnancy unless considered essential by your doctor. If the medicine is taken for long periods of time in the second or third trimesters it may cause the newborn baby to lose its hair or have problems with controlling blood sugar. Seek further medical advice from your doctor.
  • It is not known if this medicine passes into breast milk. Mothers who need to take this medicine should not breastfeed. Seek medical advice from your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Loss of appetite.
  • Feeling sick or vomiting.
  • Abdominal discomfort.
  • Diarrhoea.
  • Constipation.
  • Fluid retention (oedema), causing weight gain, bloating or swelling. You may need to take a diuretic medicine to treat this.
  • Increased level of uric acid in the blood (hyperuricaemia). This can potentially cause kidney problems and gout.
  • Low blood pressure (hypotension).
  • Increased heart rate (tachycardia).
  • Abnormal heart beats (arrhythmias).
  • Abnormal movements of the hands, legs, face, neck, eyes or tongue, eg tremor, twitching, rigidity (extrapyramidal effects).
  • Increased hair growth (hirsutism) with long-term treatment.
  • High blood glucose level (hyperglycaemia).
  • Headache.
  • Visual disturbances.
  • Muscle cramps.
  • Shortness of breath.
  • Liver or kidney problems.
  • Decrease in the normal numbers of white blood cells or platelets in your blood.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.

Diazoxide may enhance the blood pressure lowering effect of medicines that decrease blood pressure, particularly medicines that are used to treat high blood pressure (antihypertensives). This may cause dizziness, which can usually be relieved by lying down until the symptoms pass. If you feel dizzy while taking this medicine in combination with other medicines that can lower blood pressure you should let your doctor know, as your doses may need adjusting. Other medicines that decrease blood pressure include the following:

  • ACE inhibitors, eg enalapril
  • aldesleukin
  • alpha-blockers such as prazosin
  • alprostadil
  • angiotensin II receptor antagonists such as losartan
  • antipsychotics such as chlorpromazine
  • benzodiazepines, eg temazepam, diazepam
  • baclofen
  • beta-blockers such as propranolol
  • calcium-channel blockers such as verapamil, nifedipine
  • clonidine
  • diuretics, eg furosemide, bendroflumethiazide
  • dopamine agonists, eg bromocriptine, apomorphine
  • hydralazine (should not be used in combination with diazoxide)
  • levodopa
  • MAOI antidepressants, eg phenelzine
  • methyldopa
  • minoxidil
  • moxonidine
  • moxisylyte
  • nicorandil
  • nitrates, eg glyceryl trinitrate
  • tizanidine.

Diazoxide may reduce the level of the antiepileptic medicine phenytoin in the blood and could make it less effective. Phenytoin may also reduce the effects of diazoxide.

Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain diazoxide as the active ingredient.