Generic Name: Hyaluronate Sodium (HYE-al-ure-ON-ate SOE-dee-um)Brand Name: Examples include Euflexxa and Supartz

Euflexxa is used for:

Treating knee pain in patients with osteoarthritis who have not received relief from other treatments.

Euflexxa is a hyaluronic acid derivative. It works by increasing the effectiveness of the fluid within the knee joint to act as a lubricant and shock absorber.

Do NOT use Euflexxa if:

  • you are allergic to any ingredient in Euflexxa
  • you have an infection or skin disease near the joint or injection site

Contact your doctor or health care provider right away if any of these apply to you.

Before using Euflexxa :

Some medical conditions may interact with Euflexxa . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to birds or bird products (eg, eggs, feathers, poultry). Some brands of Euflexxa may contain ingredients that come from chickens.

Some MEDICINES MAY INTERACT with Euflexxa . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Quaternary ammonium salts because side effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Euflexxa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Euflexxa :

Use Euflexxa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Euflexxa comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Euflexxa refilled.
  • Euflexxa is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Euflexxa at home, a health care provider will teach you how to use it. Be sure you understand how to use Euflexxa . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Euflexxa is usually given as a series of injections 1 week apart for a total of 3 to 5 injections depending upon the particular product you are using. You may not experience relief until you have received several injections.
  • Do not use Euflexxa if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Do not use disinfectants containing ammonium salts to prepare the skin for injection because side effects may occur.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Euflexxa , contact your doctor to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Euflexxa .

Important safety information:

  • Euflexxa may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Euflexxa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • You may experience a temporary inflammation in your knee after using Euflexxa . If the inflammation is severe or continues, contact your doctor.
  • Avoid strenuous activity or prolonged (more than 1 hour) weight-bearing activity (eg, running, tennis, heavy lifting) for at least 48 hours after you are injected with Euflexxa .
  • Euflexxa should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Euflexxa , contact your doctor. You will need to discuss the benefits and risks of using Euflexxa while pregnant. It is not known if Euflexxa is found in breast milk. If you are or will be breast-feeding while you are using Euflexxa , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Euflexxa :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; mild bruising, heat, redness, swelling, or pain at the injection site; temporary achy feeling; temporary knee inflammation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately.

Proper storage of Euflexxa :

Euflexxa is usually handled and stored by a health care provider. If you are using Euflexxa at home, store Euflexxa as directed by your pharmacist or health care provider. Keep Euflexxa out of the reach of children and away from pets.

General information:

  • If you have any questions about Euflexxa , please talk with your doctor, pharmacist, or other health care provider.
  • Euflexxa is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Euflexxa . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Euflexxa injectable Concise Consumer Information (Cerner Multum)
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