Fluconazole Solution

Generic Name: Fluconazole (flue-KON-a-zole)Brand Name: Diflucan

Fluconazole Solution is used for:

Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.

Fluconazole Solution is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Fluconazole Solution if:

  • you are allergic to any ingredient in Fluconazole Solution
  • you are taking astemizole, an aldosterone blocker (eg, eplerenone), cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, a serotonin (5-HT1) receptor agonist (eg, eletriptan), or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fluconazole Solution:

Some medical conditions may interact with Fluconazole Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are immunocompromised or have liver or kidney problems
  • if you have allergies to other azole antifungals (eg, itraconazole)

Some MEDICINES MAY INTERACT with Fluconazole Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aldosterone blockers (eg, eplerenone), amiodarone, astemizole, cisapride, pimozide, serotonin receptor agonists (eg, eletriptan), macrolide antibiotics (eg, erythromycin), quinolines (eg, ciprofloxacin), or terfenadine because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
  • Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
  • Macrolide immunosuppressants (eg, tacrolimus) because the risk of kidney problems may be increased
  • Rifampin because it may decrease Fluconazole Solution's effectiveness
  • Anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cyclophosphamide, cyclosporine, ergot alkaloids (eg, ergotamine), haloperidol, HMG-CoA reductase inhibitors or "statins" (eg, simvastatin), hydantoins (eg, phenytoin), methadone, muscarinic antagonists (eg, solifenacin, tolterodine), narcotics (eg, codeine), ramelteon, sulfonylureas (eg, glipizide), theophylline, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Fluconazole Solution.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluconazole Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fluconazole Solution:

Use Fluconazole Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Fluconazole Solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Fluconazole Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Fluconazole Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • An extra patient leaflet is available with Fluconazole Solution. Talk to your pharmacist if you have questions about this information.
  • To clear up your infection completely, use Fluconazole Solution for the full course of treatment. Keep using it even if you feel better in a few days. Do not miss any doses.
  • Fluconazole Solution works best if it is taken at the same time each day.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Fluconazole Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluconazole Solution.

Important safety information:

  • Fluconazole Solution may cause dizziness, drowsiness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Fluconazole Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Fluconazole Solution has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Fluconazole Solution has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Fluconazole Solution is stopped. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Fluconazole Solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Be sure to use Fluconazole Solution for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Lab tests, including blood urea nitrogen and liver and kidney function tests, may be performed while you use Fluconazole Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Fluconazole Solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fluconazole Solution while you are pregnant. Fluconazole Solution is found in breast milk. If you are or will be breast-feeding while you use Fluconazole Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Fluconazole Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; dizziness; headache; nausea; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; pain or redness at the injection site; scaly, red skin over a large portion of the body; swollen or tender abdomen; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include changes in behavior; convulsions; hallucinations; seizures; slowed breathing.

Proper storage of Fluconazole Solution:

Store injections in glass bottles between 41 and 86 degrees F (5 and 30 degrees C), away from heat, moisture, and light. Throw away any unused portion after 2 weeks. Protect from freezing.

Store injections in plastic containers between 41 and 77 degrees F (5 and 25 degrees C), away from heat, moisture, and light. Protect from freezing. Brief exposure up to 104 degrees F (40 degrees C) will not affect the product.

Do not store in the bathroom. Keep Fluconazole Solution, as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about Fluconazole Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Fluconazole Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Fluconazole Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Fluconazole Prescribing Information (FDA)
  • Fluconazole Professional Patient Advice (Wolters Kluwer)
  • Fluconazole Detailed Consumer Information (PDR)
  • fluconazole Advanced Consumer (Micromedex) - Includes Dosage Information
  • Diflucan Prescribing Information (FDA)
  • Diflucan Consumer Overview