Ancotil infusion contains the active ingredient flucytosine, which is an antifungal medicine. It is used to treat infections caused by fungi.
Flucytosine works by affecting the metabolism of fungal cells. It is thought to work by being incorporated into the fungal cells' genetic material, DNA and RNA. Both DNA and RNA are needed for the fungi to grow, repair themselves and multiply. Flucytosine causes problems with the production of DNA and RNA in the fungal cells and this causes them to grow in an unbalanced way, causing the fungi to die.
Flucytosine is only effective against some types of fungal infections, for example cryptococcosis, candidiasis and chromomycosis. It may be used in combination with other antifungal drugs such as amphotericin or fluconazole.
In the treatment of cryptococcal meningitis and severe systemic candidiasis Ancotil is usually given in combination with amphotericin-B. Amphotericin-B may also be given in combination with Ancotil in severe or long-standing infections due to other organisms.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you or your child are already taking, including those bought without a prescription and herbal medicines, before treatment with this medicine is started. Similarly, check with your doctor or pharmacist before taking any new medicines during treatment with this one, to make sure that the combination is safe.
Fluorouracil, which is produced from flucytosine, is broken down in the body by an enzyme called dihydropyrimidine dehydrogenase (DPD). The action of DPD is inhibited by medicines known as antiviral nucleosides, such as brivudine and sorivudine. These medicines may increase the risk of side effects from fluorouracil and should not be used in people treated with flucytosine, or within four weeks of treatment with flucytosine.
If you are taking phenytoin for epilepsy your doctor will monitor the levels of phenytoin closely whilst you are having treatment with Ancotil. This medicine can increase the amount of phenytoin in the blood.
If you are having this medicine in combination with cytarabine treatment your doctor may want to monitor the levels of both medicines in your blood.
There are currently no other medicines available in the UK that contain flucytosine as the active ingredient.