FRAGMIN is used to prevent blood clots forming in blood vessels. It is used in the following conditions:
FRAGMIN is also used to prevent blood clotting during haemodialysis, a procedure that uses a machine to remove waste products from the blood in people with kidney failure.
FRAGMIN belongs to a group of medicines called low molecular weight heparins (LMWHs). These medicines work by reducing blood clotting activity.
Ask your doctor if you have any questions about why FRAGMIN has been prescribed for you.
Your doctor may have prescribed FRAGMIN for another reason.
Do not use FRAGMIN if you have an allergy to:
Some of the symptoms of allergy include skin rash, itching, difficulty breathing, and swelling of the face.
Do not use FRAGMIN if you have or ever had any of the following medical conditions:
Do not use FRAGMIN:
Do not use FRAGMIN after the expiry date printed on the pack.
Do not use FRAGMIN if the packaging is torn or shows signs of tampering.
If the product has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start treatment with FRAGMIN, talk to your doctor or pharmacist.
FRAGMIN is not recommended for use in children, as its safety and effectiveness have not been established in children.
Tell your doctor if you have allergies to any other medicines, foods, preservatives, or dyes.
Tell your doctor if you have or have had any of the following:
Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.
FRAGMIN is not recommended for use during pregnancy or breastfeeding. Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor or pharmacist about any of the above, tell them before you start treatment with FRAGMIN.
Tell your doctor or pharmacist if you are taking other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may alter the effects of FRAGMIN. These include:
If you are taking any of these medicines while using FRAGMIN, your doctor will need to carefully monitor your blood clotting factors.
These medicines may be affected by FRAGMIN or may affect how well it works. You may need to use different amounts of your medicine or you may need to use different medicines. Your doctor or pharmacist will advise you.
Your doctor or pharmacist has a complete list of medicines to be careful with or avoid while using FRAGMIN.
FRAGMIN is given by injection, either under the skin (subcutaneously) or into a vein (intravenously). The dose and length of treatment will depend on your condition. Your doctor or nurse will usually give you your injection.
If you are being treated for deep vein thrombosis, your doctor may tell you to start taking another oral medicine to prevent blood clots, such as warfarin tablets.
If you are being treated for unstable heart disease, e.g. unstable angina or heart attack, your doctor might tell you to take aspirin as well.
In certain conditions you might have to use FRAGMIN after you have left hospital. In that case, your doctor or nurse will teach you how to self-inject before you leave the hospital.
To inject FRAGMIN, you should be sitting or lying down. Do not expel the air bubble from the syringe before injection. This should ensure delivery of the full dose.
The injection is given under the skin. You can inject yourself in either your stomach or the fleshiest part of your upper buttock.
Your doctor or nurse will tell you which of these two areas is better for you to use. Whichever area you use, try to make sure that you inject yourself in slightly different spots each time to avoid soreness at the injection site.
Before you inject, make sure that the injection site is clean by wiping the area with an antiseptic swab, or by washing it with soap and water and patting it dry with a clean towel.
If you are injecting yourself in the stomach, you will need to lift up a fold of skin to make a slight bulge, as the layer of fat may be quite thin. Keep a firm grip of the skin throughout the whole injection without pinching yourself too tightly.
If you are injecting yourself in the buttock, there is no need to lift a fold of skin, as the layer of fat is thick enough.
Insert the needle into the skin vertically, as far as it will go. Press on the plunger and withdraw the needle when you have injected the whole content of the syringe.
Dispose of the used syringe and needle in a safe manner. If you have any questions, ask your doctor or nurse for help.
TWICE DAILY INJECTIONS
If it is less than 6 hours since you should have injected, give yourself an injection and then continue as usual. If more than 6 hours has passed, give yourself the next injection when it is time to do so.
ONCE DAILY INJECTIONS
If it is less than 12 hours since you should have injected, give yourself an injection as soon as you can and then continue as usual. If more than 12 hours have passed, give yourself the next injection when it is time to do so.
In either case, contact your doctor if you are concerned or have any questions.
Immediately telephone the Poisons Information Centre (telephone 13 11 26) or go to the Accident and Emergency department at your nearest hospital if you think that you or anyone else may have used too much FRAGMIN.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Keep telephone numbers of these facilities handy.
Use FRAGMIN exactly as your doctor has prescribed.
If you are about to be started on any new medicine, remind your doctor, dentist and pharmacist that you are using FRAGMIN.
If you are going to have surgery, tell your doctor, anaesthetist or dentist that you are being treated with this medicine.
Tell your doctor that you are using FRAGMIN if you are going to have a local anaesthetic or an anaesthetic injection in your back (spinal or epidural injection).
If you become pregnant while using FRAGMIN, tell your doctor immediately.
Do not give FRAGMIN to anyone else, even if they have the same condition as you.
Do not use FRAGMIN to treat any other complaints unless your doctor tells you to.
Do not stop using your medicine or change the dosage without checking with your doctor.
Do not mix FRAGMIN with other injections or infusion solutions.
Do not inject FRAGMIN into a muscle.
FRAGMIN is not interchangeable with other low molecular weight heparins (LMWHs) or heparin products.
Follow your doctor's instructions carefully and be sure to keep all medical appointments.
Your doctor may ask you to have blood tests to prevent unwanted side effects.
Tell your doctor, pharmacist or nurse as soon as possible if you do not feel well during or after treatment with FRAGMIN.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.
Ask your doctor, nurse or pharmacist to answer any questions that you may have.
Tell your doctor or pharmacist if you notice any of the following side effects:
If any of the following happen, tell your doctor immediately or go to Accident and Emergency at your nearest hospital:
The above list includes rare but very serious side effects. You may need urgent medical attention or hospitalisation.
Tell your doctor, nurse or pharmacist immediately if you notice anything that is making you feel unwell during or after treatment with FRAGMIN.
Other side effects not listed above may also occur in some patients. Some of these side effects can be found only when your doctor does tests from time to time to check your progress. (e.g. changes in liver function shown in blood tests, increased blood potassium level).
Keep the syringes in the pack until it is time to use them.
If you take the syringes out of the pack they may not keep well.
Keep FRAGMIN in a cool dry place where the temperature stays below:
The recommended storage conditions for your product are shown on the carton.
Do not store FRAGMIN or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.
Discard any unused solution.
A solution for infusion should be used within 12 hours of its preparation.
Keep FRAGMIN where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Dispose of the used syringe and needle safely in a 'sharps' container or similar puncture proof container made of hard plastic.
If your doctor tells you to stop using FRAGMIN or you find that the syringes have passed their expiry date, ask your doctor or pharmacist what to do with any that are left over.
FRAGMIN is a clear, colourless or straw-coloured solution. The solution is contained in a pre-filled glass syringe. A non-removable needle is attached to each syringe.
FRAGMIN comes in five sizes of single fixed dose syringes and two sizes of graduated single dose syringes. The 7,500 IU and 10,000 IU graduated syringes have measurement markings to allow the dose to be adjusted.
FRAGMIN contains dalteparin sodium as the active ingredient. FRAGMIN also contains water for injections and sodium chloride (only 2500 IU, 7,500 IU and 10,000 IU).