Glypressin Solution

What GLYPRESSIN is used for

GLYPRESSIN is used to treat bleeding veins in the lower end of the food-pipe in people with serious liver disease. When the liver is diseased, there is less blood flowing through it. This causes the blood to 'back up' in the veins in the lower end of the food pipe (and upper part of the stomach). The veins in the lining of the food pipe (and stomach) then become very large and stretched, much like varicose veins. Because the veins are also very fragile, they can rupture and then bleed severely into the stomach.

GLYPRESSIN contains terlipressin, a substance which acts to stop the bleeding by lowering the blood pressure in the veins of the food-pipe.

Ask your doctor if you have any questions about why GLYPRESSIN has been prescribed for you.

Your doctor may have prescribed it for another reason.

GLYPRESSIN is not addictive.

This medicine is available only with a doctor's prescription.

Before you are given GLYPRESSIN

When you must not be given it

Do not use GLYPRESSIN if you have an allergy to terlipressin, the active ingredient, or to any of the other ingredients listed at the end of this leaflet.

Symptoms of an allergic reaction to GLYPRESSIN may include:

  • shortness of breath, wheezing or difficulty breathing
  • swelling of the face, lips, tongue or other parts of the body
  • rash, itching or hives on the skin.

Do not use GLYPRESSIN if you are pregnant.

It may affect your developing baby if you are given it during pregnancy.

Do not use GLYPRESSIN if you are breast-feeding or planning to breast-feed.

It is not known if it passes into breast milk or is safe for use in infants.

Do not use GLYPRESSIN after the expiry date (EXP) printed on the pack.

If you use it after the expiry date has passed, it may not work as well.

Do not use GLYPRESSIN if the packaging is torn/damaged or shows signs of tampering.

Before you are given it

Tell your doctor if you have allergies to:

any of the ingredients listed at the end of this leaflet
any other medicines
any other substances, such as foods, preservatives or dyes.

Tell your doctor if you have or have had any medical conditions, especially the following:

heart disease
high blood pressure
irregular heartbeat
circulation problems
kidney problems.

Tell your doctor if you plan to have surgery.

If you have not told your doctor about any of the above, tell them before you start taking GLYPRESSIN.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and GLYPRESSIN may interfere with each other. These include:

  • beta blockers - used to treat high blood pressure and certain heart conditions
  • propofol, a short-acting anaesthetic
  • sufentanil, a powerful opioid painkiller (not available in Australia).

Taking GLYPRESSIN with these medicines may cause your heart to slow down or beat irregularly.

These medicines may be affected by GLYPRESSIN, or may affect how well it works. You may need different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

Your doctor and pharmacist may have more information on medicines to be careful with or avoid while taking GLYPRESSIN.

How GLYPRESSIN is given

How much you will be given

GLYPRESSIN is a medicine that is used in hospital and should only be administered by qualified staff.

Your doctor will give you the correct amount of GLYPRESSIN. The maximum dose is 1.7 mg every 4 hours.

Instructions for proper use of the drug intended for your doctor or nurse are included in the package insert.

How it is given

GLYPRESSIN will be given to you by injection in one of your veins.

How often it is given

GLYPRESSIN is usually given for up to 48 hours.

If you are given too much (overdose)

As GLYPRESSIN is given to you under the supervision of your doctor, it is very unlikely that you will receive too much.

However, if you experience any side effects after you are discharged, immediately telephone your doctor, or the Poisons Information Centre (telephone Australia 13 11 26 or New Zealand 0800 POISON or 0800 764766), or go to Accident and Emergency at your nearest hospital.

You may need urgent medical attention.

Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.

If you receive too much GLYPRESSIN, you may experience any of the following:

  • headache
  • pale skin
  • blue lips and fingernails
  • stomach pain or discomfort
  • nausea
  • diarrhoea.

While you are using GLYPRESSIN

Things you must do

Tell any other doctors, dentists, and pharmacists who are treating you that you are or have been treated with GLYPRESSIN.

If you are about to be started on any new medicine, tell your doctor, dentist or pharmacist that you are or have been treated with GLYPRESSIN.

Be sure to keep all your doctor's appointments.

Your doctor will want to do blood and other tests regularly to check on your progress and detect any unwanted side effects.

If you become pregnant while you are being given this medicine, stop taking/using it and tell your doctor or pharmacist immediately.

Things that may help your condition

Some self-help measures suggested below may help your condition.

Talk to your doctor or pharmacist about them:

  • alcohol - your doctor may advise you to limit your alcohol intake
  • diet - eat a healthy diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish. Also eat less fat and sugar
  • smoking - your doctor may advise you to stop smoking or at least cut down.

Side effects

Tell your doctor or nurse immediately if you do not feel well after you have GLYPRESSIN.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

The most frequently reported side effects are:

  • headache
  • increased blood pressure
  • slow or irregular heart beat
  • pale skin
  • blue lips and fingernails
  • stomach pain or discomfort
  • diarrhoea.

Other side effects include:

  • local irritation at the injection site
  • difficulty breathing
  • hot flushes
  • chest pain
  • heart failure
  • nausea with vomiting
  • fluid overload
  • severely abnormal heart rhythm.

Tell your doctor or nurse if you notice anything else that is making you feel unwell.

Other side effects, not listed above, may also occur in some people.

After using GLYPRESSIN

If you have any queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your pharmacist what to do with any medicine that is left over.

Product description

What it looks like

GLYPRESSIN is given as intravenous injection:

Solution for Injection

this is a clear, colourless solution containing 8.5mL of GLYPRESSIN solution (in an ampoule)
available in box containing 5 ampoules of GLYPRESSIN solution.


Active ingredient:

The active ingredient in GLYPRESSIN preparations is terlipressin.

Each ampoule of GLYPRESSIN Solution for Injection contains 0.85 mg terlipressin (equivalent to 1 mg of terlipressin acetate) in 8.5 mL solution.

Other ingredients:

Sodium chloride, Acetic acid, Sodium acetate trihydrate, Water for Injections

This medicine does not contain lactose, sucrose, gluten, tartrazine or any other azo dyes.