Granisol

Generic Name: granisetron (Oral route, Intravenous route)

gra-NIS-e-tron

Commonly used brand name(s):

In the U.S.

  • Granisol
  • Kytril

Available Dosage Forms:

  • Solution
  • Tablet

Therapeutic Class: Antiemetic

Pharmacologic Class: Serotonin Receptor Antagonist, 5-HT3

Uses For Granisol

Granisetron is used to prevent the nausea and vomiting that may occur after treatment with anticancer medicines (chemotherapy) or with radiation therapy.

Granisetron is to be given only by or under the immediate supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, granisetron injection is used in certain patients:

  • To prevent the nausea and vomiting that may occur after cancer radiation treatment in patients undergoing bone marrow transplantation.

Before Using Granisol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children 2 years of age and older and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Apomorphine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Phenobarbital

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

The presence of other medical problems may affect the use of granisetron. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abdominal (stomach) surgery, very recent or
  • Nausea and vomiting from the chemotherapy—If granisetron is taken when these medical problems exist, it may mask very serious stomach problems.

Proper Use of granisetron

This section provides information on the proper use of a number of products that contain granisetron. It may not be specific to Granisol. Please read with care.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For prevention of nausea and vomiting caused by anticancer medicine:
    • For oral dosage form (tablets):
      • Adults and teenagers—Dose is usually 1 milligram (mg) taken up to one hour before the anticancer medicine. The 1-mg dose is taken again twelve hours after the first dose. Alternatively, 2 mg may be taken as one dose, up to one hour before the anticancer medicine.
      • Children—Dose must be determined by your doctor.
    • For injection dosage form:
      • Adults and children 2 years of age or older—Dose is based on body weight and must be determined by your doctor. It is usually 10 micrograms (mcg) per kilogram (kg) (4.5 mcg per pound) of body weight. It is injected into a vein over a period of five minutes, beginning within thirty minutes before the anticancer medicine is given.
      • Children up to 2 years of age—Dose must be determined by your doctor.
  • For prevention of nausea and vomiting caused by radiation therapy:
    • For oral dosage form (tablets):
      • Adults and teenagers—Dose is 2 milligrams (two 1 milligram tablets) taken within 1 hour of radiation.
      • Children—Dose must be determined by your doctor.

Precautions While Using Granisol

Check with your doctor if severe nausea and vomiting occur after receiving the anticancer medicine.

Granisol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Blurred vision
  • fever
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Rare
  • Arm, back or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fainting
  • irregular heartbeat
  • nausea
  • shortness of breath
  • skin rash, hives, and itching
  • sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal pain
  • constipation
  • diarrhea
  • headache
  • lack or loss of strength
  • unusual tiredness or weakness
  • vomiting
Less common
  • Agitation
  • dizziness
  • drowsiness
  • fear
  • heartburn
  • indigestion
  • nervousness
  • sleepiness or unusual drowsiness
  • sour stomach
  • trouble in sleeping
  • unusual taste in mouth

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  • Granisetron Prescribing Information (FDA)
  • Granisetron MedFacts Consumer Leaflet (Wolters Kluwer)
  • Kytril Prescribing Information (FDA)
  • Kytril Consumer Overview
  • Sancuso Prescribing Information (FDA)
  • Sancuso MedFacts Consumer Leaflet (Wolters Kluwer)
  • Sancuso Consumer Overview