HepaGam B

Generic name: Hepatitis B immune globulinBrand names: HepaGam B

Why is HepaGam B prescribed?

HepaGam B is used to treat patients who have had a brief encounter (ingestion, sexual contact) with blood contaminated by the hepatitis B virus. The injection could also be used for babies born to infected mothers.

Most important fact about HepaGam B

HepaGam B is made from human plasma and therefore may contain viruses. The plasma is screened and cleaned of viruses such as HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV), but may contain infections such as Creutzfeldt-Jacob disease.

Also, there is a type of sugar (maltose) that is present in the HepaGam B injection; this sugar may interfere with antidiabetic treatments.

How should you take HepaGam B?

HepaGam B will be injected by your nurse or doctor in the upper leg (thigh), upper arm, or buttocks. If it is injected in the buttocks, it should only be given in the upper or outer regions, not in the center.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible.

  • Side effects may include:Aching joints, allergic reaction, chills, cold/flu symptoms, fainting, fever, headache, lightheadedness, nausea, vomiting

Why should HepaGam B not be prescribed?

Do not take HepaGam B if you are allergic to any of its ingredients.

Special warnings about HepaGam B

Avoid receiving any other types of vaccinations within 3 months of treatment with HepaGam B.

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with HepaGam B. Also, talk to your doctor about your complete medical history, especially if you are diabetic, pregnant, or are breastfeeding.

Possible food and drug interactions when taking HepaGam B

If HepaGam B is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining HepaGam B with any other vaccination. All other vaccinations should be avoided for at least 3 months; you may have to be revaccinated with HepaGam B after receiving a different type of live vaccination.

Special information if you are pregnant or breastfeeding

The effects of HepaGam B during pregnancy and breastfeeding are unknown. Talk with your doctor before taking HepaGam B if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for HepaGam B


Your doctor will determine the proper dosage.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • HepaGam B Consumer Overview
  • HepaGam B Advanced Consumer (Micromedex) - Includes Dosage Information
  • BayHep B MedFacts Consumer Leaflet (Wolters Kluwer)
  • Nabi-HB Prescribing Information (FDA)