Generic Name: imiglucerase (im ih GLUE ker ase)Brand Names: Cerezyme
Imiglucerase is a man-made form of the naturally-occurring protein beta-glucocerebrosidase. A deficiency of beta-glucocerebrosidase is called Gaucher disease.
Imiglucerase is used for the treatment of Type 1 Gaucher disease that results in one or more of the following: anemia (low level of red blood cells), thrombocytopenia (low level of platelets), bone disease, hepatomegaly (enlargement of the liver), or splenomegaly (enlargement of the spleen).
Imiglucerase may also be used for purposes other than those listed here.
Before using imiglucerase, tell your doctor if you have
had an allergic reaction to imiglucerase, alglucerase (Ceredase), or have antibodies to either medication; or
breathing problems or pulmonary hypertension.
You may not be able to use imiglucerase, or you may require a dosage adjustment or special monitoring during treatment.Imiglucerase is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use imiglucerase without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether imiglucerase passes into breast milk. Do not use imiglucerase without first talking to your doctor if you are breast-feeding a baby.
Use imiglucerase exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Imiglucerase is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.
Your doctor may want you to have blood tests or other medical evaluations during treatment with imiglucerase to monitor progress and side effects.
Your healthcare provider will store imiglucerase as instructed by the manufacturer. If you are storing imiglucerase at home, your healthcare provider will give you instructions regarding how to store the medication.
Contact your doctor if you miss a dose of imiglucerase.
Although symptoms of an imiglucerase overdose are not known, an overdose is unlikely to threaten life.
There are no restrictions on food, beverages, or activity during treatment with imiglucerase.
Talk to your doctor if you experience any of the following less serious side effects:
discomfort, burning, itching, swelling, or abscess (open wound or sore) at the injection site;
nausea or vomiting;
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Gaucher Disease:
Initial dosage: ranges from 2.5 units/kg of body weight 3 times a week to 60 U/kg once every 2 weeks. Imiglucerase for injection is administered by intravenous infusion over 1 to 2 hours.Dosage should be individualized to each patient. Disease severity may dictate that treatment be initiated at a relatively high dose or relatively frequent administration.
Usual Pediatric Dose for Gaucher Disease:
Greater than or equal to 2 years of age:Initial dosage: ranges from 2.5 units/kg of body weight 3 times a week to 60 U/kg once every 2 weeks. Imiglucerase for injection is administered by intravenous infusion over 1 to 2 hours.Dosage should be individualized to each patient. Disease severity may dictate that treatment be initiated at a relatively high dose or relatively frequent administration.
Imiglucerase is not expected to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including herbal products, during treatment with imiglucerase.