Trade Names:Epidrin- Capsules 65 mg isometheptene mucate, 100 mg dichloralphenazone, 325 mg APAP
Trade Names:Midrin- Capsules 65 mg isometheptene mucate, 100 mg dichloralphenazone, 325 mg APAP
Trade Names:Migratine- Capsules 65 mg isometheptene mucate, 100 mg dichloralphenazone, 325 mg APAP
Isometheptene mucate acts as sympathomimetic to constrict dilated cranial and cerebral arterioles. Dichloralphenazone is a mild sedative that reduces emotional reaction to pain of vascular and tension headaches. Acetaminophen is a mild analgesic.
Relief of tension and vascular headaches. FDA has classified drug as possibly effective in treatment of migraine headaches.
Glaucoma; severe cases of renal disease; hypertension; organic heart disease; hepatic disease; MAOI therapy.
PO 2 capsules at once, followed by 1 capsule every h until headache is relieved (max, 5 capsules in 12 h period).Tension HeadacheAdults
PO 1 to 2 capsules every 4 h (max, 8 capsules/day).
Store at room temperature in dry place in tightly closed container.
May result in severe headache, hypertension, hyperpyrexia, and possible hypertensive crisis.
None well documented.
Transient dizziness or drowsiness.
Pregnancy category undetermined.
Safety and efficacy not established.
Observe caution in patients with hypertension or peripheral vascular disease and after recent CV attacks.
Can occur with chronic ingestion of acetaminophen. Chronic alcohol abusers are especially at risk.
Nausea; vomiting; drowsiness; confusion; liver tenderness; low or high BP; cardiac arrhythmias; jaundice; acute hepatic and renal failure.
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