Joy-rides (Hyoscine hydrobromide)

How does it work?

Joy-rides tablets contain the active ingredient hyoscine hydrobromide, which is a type of medicine called an antimuscarinic (or anticholinergic). Hyoscine hydrobromide is sometimes known as scopolamine. It is used to prevent travel sickness.

Travel sickness is believed to be a result of the brain receiving conflicting information about what the body senses is happening and what the eyes see is happening.

In the inner ear are three fluid filled canals called the vestibular system. These detect changes in the body's position. Motion sickness is thought to occur when the vestibular system sends messages to the brain telling it that the body is being moved around, while the eyes send messages that the body is stationary.

Hyoscine hydrobromide is thought to prevent motion sickness by stopping the messages sent from the vestibular system from reaching an area of the brain called the vomiting centre. This area of the brain co-ordinates the vomiting reflex. Hyoscine blocks receptors called muscarinic (or cholinergic) receptors that are found in the vomiting centre. This prevents the vomiting centre from sending nerve messages to the stomach that would normally cause vomiting.

Hyoscine needs to be taken before travel to be most effective, as once feeling sick or vomiting has started it is more difficult to control, particularly with tablets that need to be kept down.

Joy-rides tablets should be taken around 20 minutes before travel to be most effective at preventing sickness, however they can also be taken once a journey has started if you begin to feel sick. For long journeys the dose may need repeating.

What is it used for?

  • Preventing travel sickness in adults and children aged three years and over.

How do I take it?

  • Joy-rides tablets can be sucked, chewed or swallowed whole. They can be taken either with or without food.
  • Adults and adolescents aged over 13 years should take two tablets 20 minutes before start of the journey. If needed, two more tablets can be taken after six hours. Do not take more than four tablets in 24 hours.
  • Children aged 7 to 12 years should be given one to two tablets 20 minutes before the start of the journey. If needed another tablet can be given after six hours. Do not give more than two tablets in 24 hours.
  • Children aged 4 to 7 years should be given one tablet 20 minutes before the start of the journey. If needed another tablet can be given after six hours. Do not give more than two tablets in 24 hours.
  • Children aged 3 to 4 years should be given half a tablet 20 minutes before the start of the journey. If needed another half a tablet can be given after six hours. Do not give more than one tablet in 24 hours.

Warning!

  • This medicine may cause drowsiness, dizziness, confusion and blurred vision. These side effects may affect your ability to drive or perform other activities that require concentration. You should not drive or operate machinary if you experience these symptoms. Do not drink alcohol, as it can worsen these side effects. If your child is affected in this way they should avoid potentially hazardous activities such as riding bikes. You should not leave your child unattended after giving them this medicine.

Use with caution in

  • Elderly people. (Elderly people may be more likely to experience side effects from this medicine).
  • People with Down's syndrome.
  • Disease involving the heart and blood vessels (cardiovascular disease).
  • Kidney disease.
  • Liver disease.
  • People with any blockage or obstruction in the stomach or intestines.
  • People with a narrowing of the outlet of the stomach that makes it difficult for food to pass into the intestines (pyloric stenosis).
  • Ulcerative colitis.
  • Diarrhoea.
  • People who have difficulty passing urine, for example men with an enlarged prostate gland (prostatic hypertrophy).
  • People with a fever. (This medicine may reduce sweating).
  • A condition involving abnormal muscle weakness (myasthenia gravis).
  • Epilepsy.

Not to be used in

  • Children under three years of age (except on medical advice).
  • People with glaucoma.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • The safety of this medicine for use during pregnancy has not been established. It should only be used during pregnancy, particularly in the first trimester, if the expected benefit to the mother outweighs any potential risk to the developing baby. Seek medical advice from your doctor before using this medicine if you are or think you could be pregnant.
  • This medicine may pass into breast milk, but only in small amounts that are unlikely to be harmful to a nursing infant. Seek medical advice from your doctor before using this medicine if you are breastfeeding.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

  • Dry mouth.
  • Drowsiness.
  • Dizziness.
  • Blurred vision or difficulty focusing.
  • Dilated pupils.
  • Reduced sweating.
  • Restlessness.
  • Confusion.
  • Hallucinations.
  • Difficulty passing urine.
  • Rash.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

If you are taking any other medicines, including those bought without a prescription and herbal medicines, it is important to check with your doctor or pharmacist before taking this medicine as well. Similarly, check with your doctor or pharmacist before taking any new medicines in combination with this one, to make sure that the combination is safe.

There may be an increased risk of drowsiness if this medicine is used in combination with any of the following (which can also cause drowsiness):

  • alcohol
  • antipsychotic medicines, eg chlorpromazine, haloperidol
  • barbiturates, eg phenobarbital
  • benzodiazepines, eg diazepam, temazepam
  • sedating antihistamines, eg chlorphenamine, brompheniramine, hydroxyzine
  • sleeping tablets, eg zopiclone
  • strong opioid painkillers, eg morphine, codeine, dihydrocodeine
  • tricyclic antidepressants, eg amitriptyline.

There may be an increased risk of antimuscarinic side effects, such as dry mouth, blurred vision or difficulty passing urine, if this medicine is used in combination with other medicines that have antimuscarinic effects, such as the following:

  • amantadine
  • antiarrhythmic medicines for irregular heartbeats, eg disopyramide, propafenone, quinidine
  • antihistamines, eg promethazine, brompheniramine, chlorphenamine, diphenhydramine, triprolidine (some of these are often found in over-the-counter cough and cold remedies)
  • antimuscarinic medicines for Parkinson's symptoms, eg procyclidine, orphenadrine, trihexiphenidyl
  • antimuscarinic medicines for urinary incontinence, eg oxybutynin, trospium, tolterodine
  • antipsychotics, eg chlorpromazine, clozapine, thioridazine
  • antisickness medicines, eg meclozine, cyclizine
  • antispasmodics, eg atropine, propantheline, hyoscine butylbromide
  • MAOI antidepressants, eg phenelzine
  • muscle relaxants, eg baclofen
  • tricyclic antidepressants, eg amitriptyline, clomipramine.

If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.

This medicine may oppose the effect of domperidone or metoclopramide. This is because metoclopramide and domperidone increase the motility of the gut, whereas hyoscine may reduce it.

Other medicines containing the same active ingredient

  • Kwells.
  • Kwells kids.
  • Scopoderm TTS.