How does it work?
Motens tablets contain the active ingredient lacidipine, which is a type of medicine called a calcium-channel blocker. This type of medicine acts on the heart and blood vessels.
Lacidipine works by slowing the movement of calcium through the muscle cells that are found in the walls of blood vessels. It does this by blocking 'calcium channels' in these muscle cells. Calcium is needed by muscle cells in order for them to contract, so by depriving them of calcium, lacidipine causes the muscle cells to relax.
Lacidipine acts specifically on the muscle cells in the walls of arteries, causing them to relax. This allows the arteries in the body to widen.
The relaxing and widening of the small arteries in the body decreases the resistance that the heart has to push against in order to pump the blood around the body. This reduces the pressure within the blood vessels. Lacidipine can therefore be used to lower high blood pressure.
What is it used for?
- High blood pressure (hypertension).
How do I take it?
- Motens tablets are taken once a day, preferably in the morning. The tablets can be taken either with or without food.
- The dose prescribed depends on your blood pressure measurements. It is important to follow the instructions given by your doctor. These will be printed on the dispensing label your pharmacist has put on the packet of medicine.
- You should not drink grapefruit juice while you are taking this medicine, as it can increase the level of lacidipine in your blood and thus increase the chance of getting side effects.
- Blood pressure lowering medicines can occasionally make you feel dizzy or weary. If you are affected, you should take care when driving or operating machinery.
- If you experience any chest pain after taking this medicine you should not take a further dose until you have consulted your doctor.
Use with caution in
- Decreased liver function.
- People with any problems with the heart's electrical message pathways.
- People with a history of heart failure or a weak heart (especially left ventricular failure).
Not to be used in
- Allergy to other related calcium-channel blockers (dihydropyridines), eg nifedipine, amlodipine.
- Angina that is increasing in severity, duration or frequency (unstable angina).
- People with a condition called aortic stenosis, which is narrowing of the main artery from the heart through which blood is pumped to the rest of the body.
- People who are having a heart attack or who have had a heart attack in the last month.
- Failure of the heart to maintain adequate circulation of blood (cardiogenic shock).
- Hereditary blood disorders called porphyrias.
- Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (Motens tablets contain lactose).
- This medicine is not recommended for children.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
- The safety of this medicine in pregnancy has not been established. It should therefore not be used during pregnancy unless the benefits to the mother outweigh any possible risks to the unborn child. If this medicine is used at term it may delay or prolong labour by relaxing the muscle of the uterus. Seek further medical advice from your doctor.
- This medicine may pass into breast milk. As there is no information available about the effect of this medicine on newborn babies, it is not recommended for use in breastfeeding mothers, unless the potential benefits to the mother outweigh any risks to the nursing infant. Seek further medical advice from your doctor.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Common (affect between 1 in 10 and 1 in 100 people)
- Awareness of your heartbeat (heart palpitations).
- Faster than normal heartbeat (tachycardia).
- Abdominal discomfort.
- Feeling sick.
- Skin reactions such as rash, itching, redness.
- Increased need to pass urine.
- Excessive fluid retention in the body tissues, resulting in swelling (oedema).
- Weakness or loss of strength (asthenia).
Uncommon (affect between 1 in 100 and 1 in 1000 people)
- Chest pain (angina). If you experience this do not take a further dose until you have consulted your doctor.
- Low blood pressure.
- Mild swelling of the gums (gingival hyperplasia).
Rare (affect between 1 in 1000 and 1 in 10,000 people)
- Muscle cramps.
- Nettle-type rash (urticaria).
- Hypersensitivity reactions such as narrowing of the airways (bronchospasm), swelling of the lips, throat and tongue (angioedema).
Very rare (affect less than 1 in 10,000 people)
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Lacidipine may have an additive effect with other medicines that decrease blood pressure, particularly other medicines used to treat high blood pressure (antihypertensives). If the combination of medicines lowers your blood pressure too much this could make you feel dizzy. If this happens to you, you should sit or lie down until the symptoms pass. If you frequently feel dizzy when taking lacidipine in combination with other medicines that can lower blood pressure you should let your doctor know, as your doses may need adjusting. Other medicines that can decrease blood pressure include the following:
- ACE inhibitors, eg enalapril
- alpha-blockers such as prazosin
- angiotensin II receptor antagonists such as losartan
- benzodiazepines, eg temazepam, diazepam
- beta-blockers such as propranolol
- other calcium-channel blockers, eg verapamil, nifedipine
- diuretics, eg furosemide, bendroflumethiazide
- dopamine agonists, eg bromocriptine, apomorphine
- MAOI antidepressants, eg phenelzine
- nitrates, eg glyceryl trinitrate
The following medicines may increase the breakdown of lacidipine by the liver, which could make it less effective. If you take any of these in combination with lacidipine your doctor may need to increase your nifedipine dose:
- the herbal remedy St John's wort (Hypericum perforatum).
The following medicines may decrease the breakdown of lacidipine by the liver, which could increase the risk of its side effects. If you take any of these with lacidipine, you should tell your doctor if you feel dizzy or experience any other side effects, as the dose of your lacidipine may need to be reduced:
- protease inhibitors for HIV infection, eg ritonavir, nelfinavir, saquinavir
The following medicines may reduce the blood pressure lowering effect of this medicine:
- corticosteroids, such as dexamethasone or prednisolone
- oestrogens, such as those in the contraceptive pill
- regular use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac or indomethacin (occasional painkilling doses are unlikely to have a significant effect).
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain lacidipine as the active ingredient.