Generic Name: levoleucovorin (LEE voe LOO koe VOE rin)Brand Names: Fusilev
Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.
Levoleucovorin is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized.
Levoleucovorin may also be used to treat toxic effects of an accidental overdose of methotrexate.Levoleucovorin should not be used to treat anemia that is caused by a lack of vitamin B12.
Levoleucovorin may also be used for other purposes not listed in this medication guide.
Tell your doctor if you are taking sulfa drugs, seizure medication, a cancer medication called fluorouracil (5FU), or a multivitamin or mineral supplement than contains folic acid.
In an emergency situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.
If possible, before you receive levoleucovorin, tell your doctor if you have:
if you are dehydrated.
In an emergency situation, it may not be possible to tell your caregivers that you are pregnant or breast-feeding before you are treated with levoleucovorin. However, make sure any doctor caring for your pregnancy or your baby knows that you have received the medication.
Levoleucovorin is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 4 hours to complete.
Levoleucovorin is usually given every 6 hours for 10 doses. You will most likely receive your first dose 24 hours after the start of your methotrexate infusion, or as soon as possible within the first 24 hours after accidental overdose.
After treatment with levoleucovorin, you will be watched to make sure the medication has been effective and you no longer have any effects of methotrexate.
To be sure this medication is not causing harmful effects, your blood will need to be tested at least once daily for a short period of time while you are receiving levoleucovorin. This will help your doctor determine if your dose needs to be adjusted.
Since this medication is given by a healthcare professional, you are not likely to miss a dose.
Symptoms of a levoleucovorin overdose are not known.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
white patches or sores inside your mouth or on your lips;
urinating more or less than usual;
numbness or tingling;
Less serious side effects may include:
nausea, vomiting, diarrhea;
stomach pain, upset stomach;
mild skin rash; or
white patches or sores inside your mouth or on your lips.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following drugs can interact with levoleucovorin. Tell your doctor if you are using any of these:
fluorouracil (5-FU, Adrucil, Efudex, Carac, Fluoroplex);
sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others);
seizure medication such as phenobarbital (Solfoton), phenytoin (Dilantin), or primidone (Mysoline); or
a multivitamin or mineral supplement than contains folic acid.
This list is not complete and there may be other drugs that can interact with levoleucovorin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.