Generic Name: Methylergonovine (meth-ill-er-goe-NOE-veen)Brand Name: Methergine

Methergine is used for:

Preventing and treating bleeding after delivery of a baby. It may also be used for other conditions as determined by your doctor.

Methergine is a uterine stimulant. It works by increasing uterine contractions, which helps reduce blood loss after the baby is delivered.

Do NOT use Methergine if:

  • you are allergic to any ingredient in Methergine
  • you are pregnant
  • you have high blood pressure or blood poisoning
  • you are taking an azole antifungal (eg, itraconazole, ketoconazole, voriconazole), certain protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, a ketolide antibiotic (eg, telithromycin), a macrolide antibiotic (eg, clarithromycin, erythromycin), or sumatriptan

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methergine :

Some medical conditions may interact with Methergine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a blood infection or a history of blood vessel problems, stroke, liver problems, kidney problems, or heart disease
  • if you have eclampsia or preeclampsia

Some MEDICINES MAY INTERACT with Methergine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clotrimazole, ergot alkaloids (eg, ergotamine), fluconazole, fluoxetine, fluvoxamine, grapefruit juice, nefazodone, saquinavir, or zileuton because they may increase the risk of Methergine 's side effects
  • Azole antifungals (eg, itraconazole, ketoconazole, voriconazole), certain protease inhibitors (eg, delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, ketolide antibiotics (eg, telithromycin ), macrolide antibiotics (eg, erythromycin, clarithromycin), or sumatriptan because the risk of severe blood vessel constriction and decreased oxygen to the brain and other tissues may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methergine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methergine :

Use Methergine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Methergine by mouth with or without food.
  • Grapefruit and grapefruit juice may increase the risk of side effects from Methergine . Talk to your doctor before including grapefruit or grapefruit juice in your diet while taking Methergine .
  • Do not use Methergine for more than 1 week unless instructed by your doctor.
  • If you miss a dose of Methergine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Methergine .

Important safety information:

  • Methergine may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Methergine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Methergine tightens the muscles of the uterus. You may experience some uterine cramping. Check with you doctor if cramps are persistent or severe.
  • Use Methergine with caution in the ELDERLY; they may be more sensitive to its effects.
  • Use Methergine with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Methergine if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Methergine is found in breast milk. If you are or will be breast-feeding while you use Methergine , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Methergine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chest pain or tightness; dizziness; fainting; fast, slow, or irregular heartbeat; hallucinations; numbness or pain of an arm or leg; seizure; severe or persistent headache, vomiting, or stomach pain; shortness of breath; sudden vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include abdominal pain; coma; difficulty breathing; nausea; numbness; seizures; severe headache or dizziness; tingling of the extremities; vomiting.

Proper storage of Methergine :

Store Methergine below 77 degrees F (20 degrees C) in a tight, light-resistant container. Keep Methergine out of the reach of children and away from pets.

General information:

  • If you have any questions about Methergine , please talk with your doctor, pharmacist, or other health care provider.
  • Methergine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Methergine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Methergine Prescribing Information (FDA)
  • Methergine Detailed Consumer Information (PDR)
  • Methergine Concise Consumer Information (Cerner Multum)