Naftidrofuryl (Praxilene)

How does it work?

Naftidrofuryl oxalate works in two main ways. Firstly, it causes the blood vessels to widen. Secondly, it increases the ability of cells to remove waste products. Both these properties make it useful in the treatment of disorders caused by decreased blood supply to a particular area of the body.In peripheral vascular diseases, the blood vessels in the extremities are narrowed and the blood and oxygen supply to cells in the hands, feet or legs is reduced. Oxygen is required by cells in order for them to remove waste products, therefore in these conditions waste products can build up. This can cause damage to cells and lead to symptoms such as pain, cramps or ulceration. Similarly, where there is a disorder of blood flow to the brain, a lack of oxygen supply can cause damage to the cells in the brain, resulting in symptoms such as confusion or decreasing mental ability.Naftidrofuryl improves these symptoms by increasing blood and oxygen supply to the affected areas and also increasing the ability of the cells to remove waste products, even in low oxygen supply.

What is it used for?

  • Disorder of blood flow to the brain (cerebral insufficiency)
  • Narrowing of blood vessels in the extremities (peripheral vascular disease)
  • Thickening of blood vessels in the brain (cerebral atherosclerosis)


  • Take this medicine with or after food.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • The safety of this medicine in pregnancy has not been established. It should therefore be used with caution during pregnancy, and only if the benefits to the mother outweigh any risks to the foetus. Seek medical advice from your doctor.
  • There is no information available about the safety of this medicine during breastfeeding. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek medical advice from your doctor.

Label warnings

  • This medication is to be swallowed whole, not chewed.
  • This medication is to be taken with plenty of water.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Rash
  • Nausea
  • Stomach pain
  • Inflammation of the liver (hepatitis)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

There are no significant interactions reported with this medicine.

Other medicines containing the same active ingredients

Naftidrofuryl oxalate