Ondansetron

Generic Name: Ondansetron (on-DAN-se-tron)Brand Name: Zofran

Ondansetron is used for:

Preventing nausea and vomiting due to cancer chemotherapy or surgery. It may also be used for other conditions as determined by your doctor.

Ondansetron is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (eg, chemotherapy).

Do NOT use Ondansetron if:

  • you are allergic to any ingredient in Ondansetron

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ondansetron :

Some medical conditions may interact with Ondansetron . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems

Some MEDICINES MAY INTERACT with Ondansetron . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antineoplastic agents (eg, cyclophosphamide) because their effectiveness may be decreased by Ondansetron

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ondansetron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ondansetron :

Use Ondansetron as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ondansetron is usually given as an injection at our doctor's office, hospital, or clinic. If you will be using Ondansetron at home, a health care provider will teach you how to use it. Be sure you understand how to use Ondansetron . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Ondansetron if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • It is important that Ondansetron be given prior to cancer chemotherapy as directed. If you miss a dose of Ondansetron , contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Ondansetron .

Important safety information:

  • Ondansetron may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Ondansetron with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Ondansetron should be used with extreme caution in CHILDREN younger than 4 months old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ondansetron while you are pregnant. It is not known if Ondansetron is found in breast milk. If you are or will be breast-feeding while you use Ondansetron , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ondansetron :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; irritation, redness, pain, or burning at the site of injection; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fever; skin tingling or numbness; trouble urinating; vision changes or loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; severe dizziness; slowed/irregular heartbeat; sudden, temporary blindness.

Proper storage of Ondansetron :

Ondansetron is usually handled and stored by a health care provider. If you are using Ondansetron at home, store Ondansetron as directed by your pharmacist or health care provider. Keep Ondansetron out of the reach of children and away from pets.

General information:

  • If you have any questions about Ondansetron , please talk with your doctor, pharmacist, or other health care provider.
  • Ondansetron is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Ondansetron . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Ondansetron Prescribing Information (FDA)
  • ondansetron Oral, Injection, Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Zofran Prescribing Information (FDA)
  • Zofran Detailed Consumer Information (PDR)
  • Zofran Consumer Overview
  • Zofran ODT Prescribing Information (FDA)