Generic Name: Orphenadrine (or-FEN-a-dreen)Brand Name: Norflex

Orphenadrine is used for:

Short-term treatment of painful muscle conditions. It is used along with rest and physical therapy. It may also be used for other conditions as determined by your doctor.

Orphenadrine is a skeletal muscle relaxant. It works by helping to decrease pain, which helps muscles to relax.

Do NOT use Orphenadrine if:

  • you are allergic to any ingredient in Orphenadrine
  • you have glaucoma, stomach or intestinal blockage, a stomach ulcer, a blockage of your bladder, certain esophagus problems (eg, blockage or trouble swallowing), enlargement of the prostate, or myasthenia gravis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Orphenadrine :

Some medical conditions may interact with Orphenadrine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (eg, sulfites)
  • if you have a history of heart problems (eg, fast or irregular heartbeat), stomach or bowel problems (eg, inflammation, enlarged colon), kidney or liver problems, increased eye pressure, or porphyria
  • if you have trouble urinating

Some MEDICINES MAY INTERACT with Orphenadrine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Potassium tablets or capsules because they may not be able to move through the stomach and bowel as well when taken with Orphenadrine
  • Propoxyphene because confusion, anxiety, or tremors may occur
  • Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased by Orphenadrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Orphenadrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Orphenadrine :

Use Orphenadrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Orphenadrine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Orphenadrine at home, a health care provider will teach you how to use it. Be sure you understand how to use Orphenadrine . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • If Orphenadrine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Orphenadrine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Orphenadrine .

Important safety information:

  • Orphenadrine may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Orphenadrine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If dizziness occurs, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Some of these products contain sulfites, which can cause allergic reactions in certain individuals (eg, asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
  • Lab tests, including blood cell counts, kidney function, and liver function, may be performed while you use Orphenadrine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Orphenadrine with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion.
  • Orphenadrine is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Orphenadrine , contact your doctor. You will need to discuss the benefits and risks of using Orphenadrine while pregnant. It is not known if Orphenadrine is found in breast milk. If you are or will be breast-feeding while you are using Orphenadrine , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Orphenadrine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness or lightheadedness; drowsiness; dry mouth; headache; nausea; stomach irritation or upset; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation, chills, fever, or sore throat; confusion; fainting; fast or irregular heartbeat; hallucinations; pain, swelling, or redness the injection site; severe or persistent tiredness or weakness; tremor; trouble urinating or inability to urinate; unusual bruising or bleeding; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; irregular heart rate; loss of consciousness; seizures.

Proper storage of Orphenadrine :

Store Orphenadrine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Orphenadrine out of the reach of children and away from pets.

General information:

  • If you have any questions about Orphenadrine , please talk with your doctor, pharmacist, or other health care provider.
  • Orphenadrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Orphenadrine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • orphenadrine Concise Consumer Information (Cerner Multum)
  • orphenadrine Advanced Consumer (Micromedex) - Includes Dosage Information
  • Antiflex Advanced Consumer (Micromedex) - Includes Dosage Information
  • Norflex Prescribing Information (FDA)