Generic Name: Repaglinide (re-PAG-li-nide)Brand Name: Prandin

Prandin is used for:

Treating type 2 (non-insulin-dependent) diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Prandin is a meglitinide antidiabetic. It works to lower blood glucose (sugar) by stimulating the release of insulin from the pancreas gland. Prandin does not work in type 1 (insulin-dependent) diabetes, because in this condition the pancreas gland is not capable of making or releasing insulin.

Do NOT use Prandin if:

  • you are allergic to any ingredient in Prandin
  • you have type 1 diabetes (insulin-dependent diabetes)
  • you have certain severe problems associated with diabetes (eg, diabetic ketoacidosis, diabetic coma)
  • you are taking gemfibrozil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prandin :

Some medical conditions may interact with Prandin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have adrenal, pituitary, liver, or kidney problems, or if you have a history of high blood acid levels (acidosis)
  • if you drink alcohol, have very poor health, have a high fever, have a severe infection or injury, or have had poor nutrition
  • if you will be having surgery

Some MEDICINES MAY INTERACT with Prandin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), chloramphenicol, cyclosporine gemfibrozil, imidazoles (eg, itraconazole, ketoconazole), macrolides and ketolides (eg, clarithromycin, erythromycin), monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), montelukast, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), probenecid, salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), or trimethoprim because the risk of side effects, such as low blood sugar, may be increased
  • Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, nicotinic acid, phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high blood sugar may be increased
  • Insulin because it may increase the risk of Prandin 's side effects
  • Barbiturates (eg, phenobarbital), carbamazepine, or rifampin because they may decrease Prandin 's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prandin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prandin :

Use Prandin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Prandin by mouth at least 15 to 30 minutes before each meal. If you skip a meal, do not take the dose for the skipped meal. If you add an extra meal, take an extra dose with that meal.
  • If you miss a dose of Prandin , skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Prandin .

Important safety information:

  • Dizziness may occur while you are taking Prandin . This effect may be worse if you take it with alcohol or certain medicines. Use Prandin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink large amounts of alcohol while you use Prandin . Talk to your doctor or health care provider before you drink alcohol while you use Prandin .
  • Follow the diet and exercise program given to you by your health care provider.
  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Prandin exactly as prescribed, tell your doctor.
  • Prandin may lower your blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or increase hunger. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
  • Tell your doctor or dentist that you take Prandin before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including fasting blood sugar and hemoglobin A1c levels, may be performed while you take Prandin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Prandin with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.
  • Prandin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Prandin while you are pregnant. It is not known if Prandin is found in breast milk. Do not breast-feed while you are taking Prandin .

Possible side effects of Prandin :

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; joint or back pain; nasal or chest congestion; sinus inflammation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fever, chills, or persistent sore throat; low blood sugar symptoms (eg, anxiety, fast heartbeat; lightheadedness; severe or persistent dizziness, drowsiness or headache; tremors; unusual sweating; weakness); severe or persistent blurred vision or other vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include confusion; dizziness; fatigue; loss of consciousness; nausea; personality changes; seizure; shakiness.

Proper storage of Prandin :

Store Prandin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prandin out of the reach of children and away from pets.

General information:

  • If you have any questions about Prandin , please talk with your doctor, pharmacist, or other health care provider.
  • Prandin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Prandin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Prandin Prescribing Information (FDA)
  • Prandin Consumer Overview
  • Prandin Detailed Consumer Information (PDR)
  • Prandin Advanced Consumer (Micromedex) - Includes Dosage Information
  • Repaglinide Professional Patient Advice (Wolters Kluwer)