Rizatriptan Orally Disintegrating Tablets

Generic Name: Rizatriptan (RYE-za-TRIP-tan)Brand Name: Maxalt-MLT

Rizatriptan Orally Disintegrating Tablets are used for:

Treating acute migraine headache with or without aura (flashing lights, wavy lines, dark spots) in adults. It should not be used to prevent migraines or cluster headaches.

Rizatriptan Orally Disintegrating Tablets are a selective serotonin receptor agonist. It works by narrowing dilated blood vessels in the brain, relieving migraine headaches.

Do NOT use Rizatriptan Orally Disintegrating Tablets if:

  • you are allergic to any ingredient in Rizatriptan Orally Disintegrating Tablets
  • you are taking ergot alkaloids (eg, ergotamine) or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
  • you have taken another serotonin receptor agonist (eg, sumatriptan) within the last 24 hours
  • you have a history of chest pain, blood flow or heart conditions, ischemic heart disease, irregular heartbeat, stroke, or uncontrolled high blood pressure

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rizatriptan Orally Disintegrating Tablets:

Some medical conditions may interact with Rizatriptan Orally Disintegrating Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are obese, postmenopausal, or smoke cigarettes
  • if you have basilar artery or hemiplegic migraines, or cluster headaches
  • if you have diabetes, kidney or liver problems, high cholesterol, high blood pressure, phenylketonuria (PKU), or a family history of coronary artery disease

Some MEDICINES MAY INTERACT with Rizatriptan Orally Disintegrating Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may decrease Rizatriptan Orally Disintegrating Tablets's effectiveness
  • Beta-blockers (eg, propranolol), ergot alkaloids (eg, ergotamine), or MAOIs (eg, phenelzine) because they may increase the actions of Rizatriptan Orally Disintegrating Tablets and the risk of Rizatriptan Orally Disintegrating Tablets's side effects
  • Dexfenfluramine, ergot alkaloids (eg, ergotamine), or sibutramine because their actions and the risk of their side effects may be increased by Rizatriptan Orally Disintegrating Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rizatriptan Orally Disintegrating Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rizatriptan Orally Disintegrating Tablets:

Use Rizatriptan Orally Disintegrating Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Rizatriptan Orally Disintegrating Tablets. Talk to your pharmacist if you have questions about this information.
  • It is not necessary to take Rizatriptan Orally Disintegrating Tablets with liquid.
  • Do not remove the blister from the outer pouch until you are ready to take Rizatriptan Orally Disintegrating Tablets. Make sure that your hands are dry when you open the blister pack. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Rizatriptan Orally Disintegrating Tablets may be taken with or without water. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
  • Take a single dose of Rizatriptan Orally Disintegrating Tablets as soon as migraine symptoms appear. A second dose may be taken if there is only a partial response or symptoms of the migraine return. However, do not take it sooner than 2 hours following the first dose. Do not take more than 30 milligrams (mg) in a 24-hour period.
  • Do not take additional doses if you do not get a response from the first dose.
  • If you miss a dose of Rizatriptan Orally Disintegrating Tablets and you still have a headache, follow your doctor's dosing instructions. Contact your doctor right away if you are unsure of what to do if you miss a dose. Do not take Rizatriptan Orally Disintegrating Tablets more often than prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rizatriptan Orally Disintegrating Tablets.

Important safety information:

  • Rizatriptan Orally Disintegrating Tablets may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Rizatriptan Orally Disintegrating Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Rizatriptan Orally Disintegrating Tablets are not intended to prevent or reduce the number of migraine attacks that you experience.
  • If you have a headache that is different from your usual migraine attacks, check with your doctor before using Rizatriptan Orally Disintegrating Tablets.
  • Phenylketonuria patients - Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
  • Diabetes patients - Rizatriptan Orally Disintegrating Tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Rizatriptan Orally Disintegrating Tablets should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rizatriptan Orally Disintegrating Tablets while you are pregnant. It is not known if Rizatriptan Orally Disintegrating Tablets are found in breast milk. If you are or will be breast-feeding while you use Rizatriptan Orally Disintegrating Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Rizatriptan Orally Disintegrating Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; fatigue; nausea; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; changes in vision; chest pain, heaviness, or pressure; cold, tingling, or numb hands or feet; fainting or unsteadiness; fast or irregular heartbeat; pain or tightness in jaw or neck; seizures; stomach pain; unusual weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include slow, fast, or irregular heartbeat; unusual dizziness or drowsiness; vomiting.

Proper storage of Rizatriptan Orally Disintegrating Tablets:

Store Rizatriptan Orally Disintegrating Tablets at room temperature, between 59 to 86 degrees F (15 to 30 degrees C). Store away from heat, light, and moisture. Keep Rizatriptan Orally Disintegrating Tablets in the blister with the outer aluminum pouch until ready to use. Keep Rizatriptan Orally Disintegrating Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Rizatriptan Orally Disintegrating Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Rizatriptan Orally Disintegrating Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rizatriptan Orally Disintegrating Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.