Salazopyrin EN-tabs contain the active ingredient sulfasalazine, which is a type of medicine called an aminosalicylate. (NB. Sulfasalazine is also available without a brand name, ie as the generic medicine.) It is used to reduce inflammation in inflammatory bowel diseases and rheumatoid arthritis.
It is not fully understood how sulfasalazine works, but it is known to have antibacterial and anti-inflammatory actions. It reduces the actions of substances in the body that produce inflammation.
In Crohn's disease and ulcerative colitis, sulfasalazine reduces the inflammation in the gut that causes flare-ups of these diseases. It is therefore used to control flare-ups, and is also used as a maintenance treatment for ulcerative colitis to prevent further flare-ups.
In rheumatoid arthritis, sulfasalazine reduces inflammation and damage in the joints, and therefore reduces joint swelling and stiffness. It can take up to six weeks for the full effect to be seen in rheumatoid arthritis. In this disease sulfasalazine is known as a disease-modifying antirheumatic drug (DMARD). It is usually only used when non-steroidal anti-inflammatory drugs (NSAIDs) are not working.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.
You should not take indigestion remedies (antacids) at the same time of day as Salazopyrin EN-tabs. This is because Salazopyrin EN-tabs have a special coating that lets them pass through the stomach and into the intestine, where the medicine is needed. Indigestion remedies reduce the acidity in the stomach, which could allow the tablets to dissolve there rather than letting them reach the intestine.
Sulfasalazine may interfere with the absorption of the following medicines from the gut, and hence reduce their blood levels:
There may be an increased risk of side effects on the blood cells if sulfasalazine is used in combination with azathioprine or mercaptopurine.
If you have diabetes, treatment with this medicine may alter the control of your blood sugar. As a result, you may need an adjustment in your dose of antidiabetic tablets. If you have diabetes you should discuss this with your doctor.
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Sulfasalazine tablets and suspension are also available without a brand name, ie as the generic medicine.