• It may take a week or two after starting this treatment before you begin to feel the benefit. Do not stop taking paroxetine, thinking it is not helping.
  • Tell your doctor if you feel that you are getting worse or if you experience any troublesome side-effects.
  • Paroxetine may slow your reactions. If this happens, do not drive or use tools or machines.

About paroxetine

Type of medicine Selective serotonin reuptake inhibitor (SSRI)
Used for Depression
Obsessive-compulsive disorder
Panic disorder
Anxiety disorders
Post-traumatic stress disorder
Also called Seroxat®
Available as Tablets
Oral liquid

Anyone can develop depression. It can develop for no apparent reason or it may be triggered by a life event such as a relationship problem, bereavement, or illness.

Brain cells called neurons, release a number of chemicals which go on to stimulate other neurons leading to electrical impulses which result in many functions controlled by the brain. Serotonin is one such chemical in the brain. Once released, it stimulates other neurons and is then taken back up into the neuron cells and recycled. Antidepressants like paroxetine increase the amount of circulating serotonin available in the brain. This may help depression symptoms in some people.

Although paroxetine is often used to treat depression, it can also reduce the symptoms of obsessive-compulsive disorder (OCD) and anxiety disorders.

Before taking paroxetine

Before taking paroxetine make sure your doctor or pharmacist knows:

  • If you are under 18 years of age.
  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have heart, kidney or liver problems.
  • If you have epilepsy.
  • If you have diabetes.
  • If you have glaucoma (increased pressure in your eye).
  • If you have a bleeding disorder.
  • If you have ever had abnormally 'high' moods.
  • If you are being treated with electroconvulsive therapy (ECT).
  • If you have ever had an allergic reaction to this or to any other medicine.
  • If you have taken an antidepressant known as a monoamine-oxidase inhibitor (MAOI) within the previous two weeks.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take paroxetine

  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • Take paroxetine exactly as your doctor has told you. It is usually taken once each day in the morning.
  • Take paroxetine with a snack or after eating a meal.
  • If you are taking paroxetine tablets, swallow them whole with a drink of water. Do not crush or chew the tablets.
  • If you are taking paroxetine oral liquid, do not take indigestion remedies for the two hours before and the two hours after you take the medicine.
  • Try to take your doses at the same time each day as this will help you to avoid missing any.
  • If you do forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • You may feel that paroxetine is not working for you straightaway. It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or so, thinking it is not helping.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • You are advised not to drink alcohol while you are being treated with paroxetine. Taking paroxetine and alcohol may increase the chance that you experience side-effects.
  • If you have diabetes you may need to check your blood glucose more frequently, as paroxetine may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
  • Paroxetine may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and sunbeds until you know how your skin reacts.
  • If you buy any medicines, check with a pharmacist that they are safe to take with paroxetine.
  • There are several types of antidepressants and they differ in their possible side-effects. If you find that paroxetine does not suit you then let your doctor know, as another may be found that will.
  • Do not stop taking paroxetine unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually if this is necessary.
  • While you feel depressed or are taking paroxetine, you may have thoughts about harming yourself or ending your life. It is very important that you tell your doctor about this if it happens.
  • If you are taking paroxetine for depression, you should expect that a normal course of treatment will last for around six months after your symptoms have eased.

Can paroxetine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common paroxetine side-effects - these affect around 1 in 10 people who take this medicine What can I do if I experience this?
Feeling or being sick, diarrhoea Stick to simple foods and drink plenty of water
Sleepiness, dizziness, weakness If this happens, do not drive or use tools or machines
Dry mouth Try chewing sugar-free gum or sweets
Headache Ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor
Feeling restless, shaky, nervous, anxious or agitated This may happen when you first start taking paroxetine but usually settles within a few days. If it becomes troublesome or severe, speak with your doctor
Constipation Try to eat a well-balanced diet containing plenty of fibre and drink plenty of water
Increased sweating, yawning, blurred vision, difficulty sleeping, abnormal dreams, lack of appetite, weight changes, sexual difficulties If any of these become troublesome, speak with your doctor

Important: if you develop any of the following, contact your doctor straightaway or go to the accident and emergency department of your local hospital:

  • Any swelling of the mouth or face.
  • Any shortness of breath or difficulty swallowing.
  • An itchy rash.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store paroxetine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.