Timoptol-LA gel-forming opthalmic solution contains the active ingredient timolol maleate, which is a type of medicine called a beta-blocker. It works by blocking beta-receptors in the eye.
The pressure within the eyeball is naturally maintained by a continuous flow of liquid called aqueous humour through the eyeball. Aqueous humour is produced by a part of the eye called the ciliary body, and it drains out of the eyeball through channels called the trabecular meshwork. If the outflow of aqueous humour is blocked, the aqueous humour builds up inside the eye, increasing the pressure within the eyeball. This pressure needs to be reduced, as otherwise it can damage the optic nerve and impair vision as a result.
Timolol blocks beta-receptors that are found on the ciliary body. This action reduces the amount of aqueous humour that is secreted into the eyeball by the ciliary body. Timolol also blocks beta-receptors found on the blood vessels that supply the ciliary body. This causes the blood vessels to constrict, and reduces the amount of watery fluid that filters out of the blood vessels to form aqueous humour.
Timolol therefore works by reducing the inflow of aqueous humour into the eyeball, which decreases the pressure within the eye. It is used to treat conditions where there is raised pressure in the eye, such as glaucoma.
Timoptol-LA is an eye drop that becomes a gel when it is administered into the eye. The gel has a longer acting effect in the eye that standard Timoptol drops, with less of the medicine being absorbed into the bloodstream. Timoptol-LA drops are used once a day, preferably in the morning.
Although less of the timolol from Timoptol-LA is absorbed into the bloodstream than from standard timolol eye drops, sufficient may still be absorbed to cause side effects on other parts of the body, or to react with medicines being taken by mouth, injection or suppository. You can minimise the amount of medicine that is absorbed into your bloodstream and increase the local action in the eye, by pressing on your tear duct (the corner of the eye closest to the nose) while putting in the drops and for a few minutes after.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
The timolol in this eye gel can be absorbed into the bloodstream after application to the eye and it may therefore interact with other medicines that you are taking. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.
If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use this eye gel last.
This medicine should not generally be used in combination with the following medicines:
If this medicine is used by people taking calcium channel blockers such as nifedipine, there may be an increased risk of slow heart rate, low blood pressure or heart failure.
If this medicine is used with any of the following there may be an increased risk of slow heart rate:
If this medicine is used with clonidine, there is a risk of a rebound increase in blood pressure if the clonidine is stopped suddenly. If the clonidine needs to be stopped, this medicine should be stopped several days before slowly stopping the clonidine.
In people with diabetes, timolol can prolong the lowering of blood sugar (hypoglycaemia) caused by insulin or other antidiabetic medicines. People with diabetes should monitor their blood sugar, as timolol can also mask the signs of hypoglycaemia.
Timolol eye drops are also available without a brand name, ie as the generic medicine.