Treanda

Generic Name: Bendamustine (BEN-da-MUS-teen)Brand Name: Treanda

Treanda is used for:

Treating chronic lymphocytic leukemia (CLL). It is also used to treat a certain type of non-Hodgkin lymphoma (NHL) in certain patients. It may also be used for other conditions as determined by your doctor.

Treanda is an alkylating agent. It works by blocking the growth of cancer cells.

Do NOT use Treanda if:

  • you are allergic to any ingredient in Treanda (including mannitol)
  • you have moderate to severe liver problems
  • you have severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Treanda :

Some medical conditions may interact with Treanda . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (eg, mannitol)
  • if you have an infection, liver or kidney problems, other types of cancer, or bone marrow depression
  • if you smoke or have a history of tobacco use

Some MEDICINES MAY INTERACT with Treanda . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Ciprofloxacin or fluvoxamine because they may increase the risk of Treanda 's side effects
  • Omeprazole because it may decrease Treanda 's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Treanda may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Treanda :

Use Treanda as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Treanda is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Treanda at home, a health care provider will teach you how to use it. Be sure you understand how to use Treanda . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Treanda if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If Treanda accidentally spills on your skin, wash it off right away with soap and water.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Treanda , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Treanda .

Important safety information:

  • Treanda may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Treanda with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Treanda may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • If you may become pregnant, you must use an effective form of birth control while you receive Treanda and for 3 months after you stop it. If you have questions about effective birth control, talk with your doctor.
  • Men who take Treanda should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you take Treanda and for 3 months after you stop taking it.
  • Treanda may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Check with your doctor before having immunizations (vaccinations) while you are using Treanda .
  • Tell your doctor or dentist that you take Treanda before you receive any medical or dental care, emergency care, or surgery.
  • Use of Treanda may increase your risk of developing another cancer. Discuss any questions or concerns with your doctor.
  • Lab tests, including blood chemistry, uric acid levels, complete blood cell counts, or liver or kidney function, may be performed while you use Treanda . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Treanda should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Treanda may cause harm to the fetus. Avoid becoming pregnant while you are using Treanda and for 3 months after you stop Treanda . If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Treanda while you are pregnant. It is not known if Treanda is found in breast milk. Do not breast-feed while taking Treanda .

Possible side effects of Treanda :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; cough; diarrhea; drowsiness; dry mouth; headache; loss of appetite; mild fever; mild itching, pain, redness, or swelling at the injection site; mouth sores; nausea; stomach pain; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fast or irregular heartbeat; fever, chills, or persistent sore throat; persistent or severe cough; redness, swelling, peeling, or blistering of the skin; severe or persistent tiredness or weakness; shortness of breath; unusual bruising or bleeding; unusual swelling; unusual weight loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include irregular heartbeat; loss of coordination; seizures; severe drowsiness; tremor; trouble breathing.

Proper storage of Treanda :

Treanda is usually handled and stored by a health care provider. If you are using Treanda at home, store Treanda as directed by your pharmacist or health care provider. Keep Treanda out of the reach of children and away from pets.

General information:

  • If you have any questions about Treanda , please talk with your doctor, pharmacist, or other health care provider.
  • Treanda is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Treanda . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Treanda Prescribing Information (FDA)
  • Treanda Advanced Consumer (Micromedex) - Includes Dosage Information
  • Treanda Consumer Overview