Generic Name: Choline and Magnesium Trisalicylates (KOE-leen and mag-NEE-zee-um tri-sa-LI-si-lates)Brand Name: Examples include Tricosal and Trilisate

Children and teenagers should not use aspirin, aspirin-containing, or aspirin-related medicines for flu symptoms or chickenpox without first consulting a doctor. A rare but serious illness known as Reye syndrome may occur. Tricosal contains an aspirin-related component.

Tricosal is used for:

Relieving signs and symptoms of rheumatoid arthritis, osteoarthritis, and acute shoulder pain. It may also be used to relieve mild to moderate pain and to reduce fever.

Tricosal is a salicylate. It works by reducing inflammation in the joints.

Do NOT use Tricosal if:

  • you are allergic to any ingredient in Tricosal or to nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen)
  • you have a blood-clotting disease (including von Willebrand disease), bleeding, or hemophilia
  • the patient is a child or teenager with flu symptoms or chickenpox
  • you are taking probenecid or sulfinpyrazone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tricosal :

Some medical conditions may interact with Tricosal . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach problems, ulcers, fever, nasal polyps, stroke, bleeding in the brain, vitamin K deficiency, chickenpox, blood-clotting problems, liver or kidney problems, or the flu

Some MEDICINES MAY INTERACT with Tricosal . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, meglitinide antidiabetics (eg, repaglinide), methotrexate, steroids (eg, dexamethasone), or valproic acid because the risk of their side effects may be increased by Tricosal
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), probenecid, or sulfinpyrazone because their the effectiveness may be decreased by Tricosal

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tricosal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tricosal :

Use Tricosal as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Tricosal by mouth with or without food. If stomach upset occurs, take with food or a large glass of milk to reduce stomach irritation.
  • Take Tricosal with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Tricosal .
  • If you miss a dose of Tricosal and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tricosal .

Important safety information:

  • Tricosal may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tricosal with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Talk to your doctor before you take Tricosal if you drink more than 3 drinks with alcohol per day.
  • Tricosal may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Tricosal .
  • Tricosal has a salicylate in it. Before you start any new medicine, check the label to see if it has a salicylate in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Tell your doctor or dentist that you take Tricosal before you receive any medical or dental care, emergency care, or surgery.
  • Tricosal should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tricosal while you are pregnant. Tricosal is found in breast milk. If you are or will be breast-feeding while you use Tricosal , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tricosal :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; heartburn; indigestion; nausea; sweating; stomach pain; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood in the stool; confusion; flushing; hallucinations; hearing loss; ringing in the ears; severe stomach pain; unusual bruising, bleeding, or black stools; vomit that looks like coffee grounds; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include bloody stools; disorientation; drowsiness; general body discomfort; hallucinations; loss of consciousness; nausea; ringing in the ears; seizures; stupor; upset stomach; vomiting; wheezing.

Proper storage of Tricosal :

Store Tricosal at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tricosal out of the reach of children and away from pets.

General information:

  • If you have any questions about Tricosal , please talk with your doctor, pharmacist, or other health care provider.
  • Tricosal is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Tricosal . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Tricosal Advanced Consumer (Micromedex) - Includes Dosage Information
  • Tricosal Concise Consumer Information (Cerner Multum)
  • Choline magnesium trisalicylate Detailed Consumer Information (PDR)