Generic Name: Trifluoperazine (trye-floo-oh-PER-a-zeen)Brand Name: Generic only. No brands available.

Trifluoperazine is used for:

Treating schizophrenia. It may also be used for the short-term treatment of certain types of anxiety. It may also be used for other conditions as determined by your doctor.

Trifluoperazine is a phenothiazine. It works by blocking dopamine receptors in the brain.

Do NOT use Trifluoperazine if:

  • you are allergic to any ingredient in Trifluoperazine or to other phenothiazines (eg, chlorpromazine)
  • you have bone marrow problems, certain blood problems, or liver damage
  • the patient is in a coma or has severe drowsiness caused by certain medicines
  • you are taking pergolide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trifluoperazine :

Some medical conditions may interact with Trifluoperazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of seizures, brain cancer, brain injury, lung or breathing problems (eg, asthma, emphysema), alcohol abuse, or depression
  • if you have a history of heart problems (eg, angina, mitral valve problems), blood problems, neuroleptic malignant syndrome (NMS), Parkinson disease, glaucoma, high or low blood pressure, or prostate problems
  • if you have stomach or bowel blockage, an adrenal gland tumor (pheochromocytoma), trouble urinating, or Reye syndrome
  • if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk for breast cancer
  • if you have been very ill, have had very poor nutrition, or will be exposed to very high temperatures

Some MEDICINES MAY INTERACT with Trifluoperazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Lithium because a severe side effect that may include weakness, sluggishness, fever, confusion, uncontrolled muscle movements, and increased white blood cell levels may occur
  • Phenytoin because its effectiveness may be decreased and the risk of its side effects may be increased by Trifluoperazine
  • Tramadol because the risk of seizures may be increased
  • Anticholinergics (eg, benztropine), diuretics (eg, hydrochlorothiazide), or propranolol because they may increase the risk of Trifluoperazine 's side effects
  • Antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), epinephrine, opiates (eg, codeine), or polypeptide antibiotics (eg, polymyxin B) because the risk of their side effects may be increased
  • Anticoagulants (eg, warfarin), guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Trifluoperazine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trifluoperazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trifluoperazine :

Use Trifluoperazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Trifluoperazine by mouth with or without food.
  • If you miss a dose of Trifluoperazine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trifluoperazine .

Important safety information:

  • Trifluoperazine may cause drowsiness, dizziness, fainting, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Trifluoperazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Trifluoperazine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Trifluoperazine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • NMS is a possibly fatal syndrome that can be caused by Trifluoperazine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take Trifluoperazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Trifluoperazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Trifluoperazine .
  • Tell your doctor or dentist that you take Trifluoperazine before you receive any medical or dental care, emergency care, or surgery.
  • Trifluoperazine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Trifluoperazine may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Trifluoperazine may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts or decreased sexual ability in men, or missed menstrual period or nipple discharge in women. Contact your doctor right away if any of these symptoms occur.
  • Trifluoperazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Trifluoperazine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Diabetes patients - Trifluoperazine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Trifluoperazine may interfere with certain lab tests, including tests for phenylketonuria (PKU) and pregnancy tests. Be sure your doctor and lab personnel know you are taking Trifluoperazine .
  • Use Trifluoperazine with caution in the ELDERLY; they may be more sensitive to its effects.
  • Trifluoperazine should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Trifluoperazine may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trifluoperazine while you are pregnant. Trifluoperazine is found in breast milk. Do not breast-feed while taking Trifluoperazine .

If you stop taking Trifluoperazine suddenly, you may have WITHDRAWAL symptoms. These may include dizziness, nausea, shakiness, upset stomach, and vomiting.

Possible side effects of Trifluoperazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; blurred vision; constipation; dizziness; drowsiness; dry mouth; headache; mild agitation or jitteriness; nasal congestion; nausea; tiredness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; decreased facial expression; fainting; fever, chills, or sore throat; irregular heartbeat; missed menstrual period; muscle weakness; new or worsening mental or mood problems; prolonged or painful erection; seizures; severe or persistent dizziness or drowsiness; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; persistent nausea, stomach pain, or loss of appetite); symptoms of heart attack (eg, chest pain, numbness of an arm or leg, sudden shortness of breath or vomiting); trouble urinating; trouble walking, speaking, or swallowing; uncontrolled muscle spasms or movements (eg, of the arms, legs, tongue, jaw, cheeks, neck; lip smacking or puckering; puffing of the cheeks; twitching; tremors); unusual bruising or bleeding; unusual restlessness; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include agitation; coma; irregular heartbeat; muscle spasms or uncontrolled muscle movements; restlessness; seizures; severe drowsiness or dizziness; tremors.

Proper storage of Trifluoperazine :

Store Trifluoperazine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trifluoperazine out of the reach of children and away from pets.

General information:

  • If you have any questions about Trifluoperazine , please talk with your doctor, pharmacist, or other health care provider.
  • Trifluoperazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trifluoperazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • trifluoperazine Concise Consumer Information (Cerner Multum)