Generic name: Bupropion hydrochlorideBrand names: Wellbutrin XL, Wellbutrin SR, Wellbutrin
Wellbutrin is prescribed to help relieve major depression. Symptoms include a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and sometimes, suicidal thoughts or behavior. Wellbutrin is thought to work by altering levels of the brain chemicals norepinephrine and dopamine.
Wellbutrin is associated with an increased risk of seizures. This risk is greater at higher doses (approximately 4 in 1,000 patients at dosages of 300 to 450 milligrams a day). Certain factors increase the risk of seizure, including:A history of head trauma or previous seizureCentral nervous system tumorSevere liver disease such as cirrhosisA history of eating disorders, including anorexia and bulimiaExcessive use of alcohol, or abrupt withdrawal from alcohol or sedativesTaking medications that lower the seizure threshold (see "Possible food and drug interactions when taking Wellbutrin SR")
To minimize the risk of seizures, dose increases should be done gradually, and the total daily dose of Wellbutrin should not exceed 450 milligrams. Additionally, the doctor should be aware of all your medical conditions, and you should not take any other medications (both prescription and over-the-counter) unless the doctor approves.
Take Wellbutrin exactly as prescribed by your doctor. The usual dosing regimen is 3 equal doses spaced evenly throughout the day. Allow at least 6 hours between doses. Your doctor will probably start you at a low dosage and gradually increase it; this helps minimize side effects.
You should take Wellbutrin SR, the sustained-release form, in 2 doses, at least 8 hours apart. Wellbutrin XL extended-release tablets should be taken once a day in the morning. Swallow Wellbutrin SR and Wellbutrin XL tablets whole; do not chew, divide, or crush them.
If Wellbutrin works for you, your doctor will probably have you continue taking it for at least several months.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Wellbutrin.
Side effects of Wellbutrin SR may include:
Agitation, constipation, dizziness, dry mouth, insomnia, nausea, rash, sweating, weight loss
Side effects of Wellbutrin XL may include:
Abdominal pain, agitation, anxiety, constipation, diarrhea, dizziness, dry mouth, heart palpitations, increased urination, insomnia, muscle soreness, nausea, rash, ringing in the ears, sore throat, sweating,
Do not take Wellbutrin if you are sensitive to or have ever had an allergic reaction to it.
Since Wellbutrin causes seizures in some people, do not take it if you have any type of seizure disorder or if you are taking another medication containing bupropion, such as Zyban, a drug that's used to help quit smoking. If you have a seizure while taking Wellbutrin, stop taking the drug and never take it again.
Do not take Wellbutrin while abruptly giving up alcohol or sedatives, including tranquilizers antianxiety drugs such as diazepam and alprazolam. Rapid withdrawal increases the risk of seizures.
If you have had any kind of heart trouble or liver or kidney disease, be sure your doctor knows about it before you start taking Wellbutrin SR. It must be used with extreme caution if you have severe cirrhosis of the liver. A reduced dosage may be needed if you have any sort of liver or kidney problem.
You should not take Wellbutrin if you currently have, or formerly had, an eating disorder. For some reason, people with a history of anorexia nervosa or bulimia seem to be more likely to experience Wellbutrin-related seizures. Do not take Wellbutrin if, within the past 14 days, you have taken a monoamine oxidase (MAO) inhibitor such as the antidepressants phenelzine or tranylcypromine. This particular drug combination could cause you to experience a sudden, dangerous rise in blood pressure.
In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Wellbutrin or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Wellbutrin has not been studied in children or adolescents and is not approved for treating anyone less than 18 years old.
Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Wellbutrin and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly—especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior—and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.
Be sure to let the doctor know if you have heart trouble, liver problems, or kidney disease before you start taking Wellbutrin. Use Wellbutrin SR with extreme caution if you have cirrhosis of the liver.
Stop taking Wellbutrin and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out with itchy eruptions. These are warning signs of a potential severe allergic reaction.
Wellbutrin may affect your coordination or judgment and impair your ability to drive or operate dangerous machinery. Avoid activities that require full alertness until you know how the drug affects you.
Like all antidepressants, Wellbutrin could trigger a manic episode in people with bipolar disorder.
Although Wellbutrin occasionally causes weight gain, a more common effect is weight loss: About a quarter of people who took Wellbutrin SR in clinical studies lost 5 pounds or more. If depression has already caused you to lose weight, and if further weight loss would be detrimental to your health, Wellbutrin may not be the best antidepressant for you.
Do not drink alcohol while you are taking Wellbutrin; an interaction between alcohol and Wellbutrin could increase the possibility of a seizure.
Wellbutrin should not be combined with drugs that lower the seizure threshold, including:Antidepressants classified as MAO inhibitors, such as phenelzine and tranylcypromineOther antidepressantsAntipsychotic drugs such as chlorpromazineCocaineDiabetes medications, including insulinOpiates such as heroin and morphineSedatives, including benzodiazepines such as alprazolamSteroid medications such as prednisoneStimulants, including over-the-counter diet drugsTheophyllineIf Wellbutrin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Wellbutrin with the following:Beta-blockers (used for high blood pressure and heart conditions) such as propranololCarbamazepineCimetidineCyclophosphamideHeart-stabilizing drugs such as certain antiarrhythmicsLevodopaNicotine patchesOrphenadrinePhenobarbitalPhenytoin
If you are pregnant or plan to become pregnant, notify your doctor immediately. Wellbutrin should be taken during pregnancy only if clearly needed.
Wellbutrin does pass into breast milk and may cause serious reactions in a nursing baby; therefore, if you are a new mother, you may need to discontinue breastfeeding while you are taking Wellbutrin SR.
No single dose of Wellbutrin should exceed 150 milligrams.
At the beginning, your dose will probably be 200 milligrams per day, taken as 100 milligrams 2 times a day. After at least 3 days at this dose, your doctor may increase the dosage to 300 milligrams per day, taken as 100 milligrams 3 times a day, with at least 6 hours between doses. This is the usual adult dose. The maximum recommended dosage is 450 milligrams per day taken in doses of no more than 150 milligrams each.
The usual starting dose is 150 milligrams in the morning. After 3 days, if you do well, your doctor will have you take another 150 milligrams at least 8 hours after the first dose. It may be 4 weeks before you feel the benefit and you will take the drug for several months. The maximum recommended dose is 400 milligrams a day, taken in doses of 200 milligrams each.
If you have severe cirrhosis of the liver, your dosage should be no more than 75 milligrams once a day. With less serious liver and kidney problems, the dosage will be reduced as needed.
The usual starting dose is 150 milligrams taken once a day in the morning. If this dose is well tolerated after a minimum of 3 days, the doctor may increase the dose to 300 milligrams, also taken once a day in the morning. If no improvement is seen after several weeks of treatment, the doctor may increase the dose to a maximum of 450 milligrams once a day.
If you have severe liver damage, use Wellbutrin SR with extreme caution. Your dose should not exceed 150 milligrams every other day. People with mild to moderate liver damage or kidney impairment will be prescribed a lower dose as well.
The safety and effectiveness in children under 18 years old have not been established.
There have been rare reports of death after an overdose of Wellbutrin. If you suspect an overdose, seek medical attention immediately.