Doxepin cream helps to reduce itching due to eczema.

Apply a thin layer of cream 3-4 times daily.

It can make you feel sleepy. If this happens, do not drive or use tools or machines.

About doxepin cream

Type of medicine Antipruritic
Used for Itching due to eczema
Also called Xepin®
Available as Cream

Eczema is sometimes called dermatitis, which means inflammation of the skin. If you have eczema, areas of your skin become dry, red and inflamed. These areas of inflamed skin are often itchy, making you want to scratch. Then when you scratch, your skin becomes even more inflamed.

Doxepin cream helps to reduce itching. It does this by blocking the action of a chemical called histamine.

Before using doxepin cream

To make sure this is the right treatment for you, before you start using doxepin cream it is important that your doctor knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have a heart condition or an irregular heart rhythm.
  • If you have glaucoma (increased pressure in your eye).
  • If you have any difficulties passing urine.
  • If you have any problems with the way your liver works.
  • If you have a mental health problem called mania.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.

How to use doxepin cream

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about doxepin cream and a full list of side-effects which you may experience from using it.
  • Apply a thin layer of doxepin cream to the itchy areas three or four times each day. It is recommended that you do not use more than 3 g of cream at any time, or more than 12 g of cream a day. As a rough guide, this means that you should never use so much that a 30 g tube of cream lasts less than three days.

Getting the most from your treatment

  • Continue to use your emollients every day as this will also help to prevent your skin from becoming dry and itchy. Try to avoid extremes of temperature by wrapping up well in cold weather. Also, avoid wearing rough or irritating clothing which can make your itching worse.
  • Doxepin cream may make you feel sleepy, especially when you first start using it. If it happens to you, do not drive or use tools or machines until you feel more awake. If it continues to be a problem, apply less cream or, for a few days, reduce the number of times you apply it. Do not drink alcohol, as this will increase the feelings of drowsiness.
  • If the treated areas of your skin are covered (either with your clothing or a dressing), this can increase how much doxepin your skin absorbs and the chance of side-effects. Do not apply more of the cream than your doctor has told you to, and do not use any dressings over the cream unless your doctor has said to do so.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using doxepin.

Can doxepin cream cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common doxepin cream side-effects
What can I do if I experience this?
Feeling sleepy If this happens, do not drive or use tools or machines.
Do not drink alcohol
Burning, stinging or tingling of your skin This should soon pass, but you can try using less cream
for a few days
Rash This could be an allergic type of reaction.
Stop using the cream and see your doctor for further advice

How to store doxepin cream

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.