Xepin cream contains the active ingredient doxepin hydrochloride. Doxepin is a medicine that is related to the tricyclic antidepressants. However, when doxepin is applied to the skin it can relieve itching. Xepin cream is used for this purpose.
It is thought that doxepin relieves itching by blocking histamine receptors in the skin. Histamine is one of many substances in the body that causes itching. It is released when the body reacts to a foreign substance (known as an allergen). The released histamine binds to its receptors (H-1 receptors) causing a chain reaction that includes an increase in blood flow to the area, and the release of other chemicals that add to the allergic response. Itching is one of the results and is an important feature of eczema.
Doxepin cream is thought to work by blocking histamine receptors in the skin, therefore reducing some of the reactions that cause itching associated with eczema. The medicine is also absorbed through the skin into the bloodstream and can cause some drowsiness. This may also help to relieve the itch of eczema.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Doxepin from Xepin cream can be absorbed into the bloodstream through the skin. This means that it can potentially interact with other medicines taken by mouth in the same way as doxepin taken by mouth, although to a lesser extent.
For this reason, it is important to tell your doctor or pharmacist what medicines you are already using, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to make sure that the combination is safe.
This medicine should not be used by people who are taking a monoamine oxidase inhibitor antidepressant (MAOI), eg phenelzine, tranylcypromine, isocarboxazid, or moclobemide, or by people who have stopped treatment with one of these medicines in the previous two weeks.
There may be an increased risk of drowsiness if this medicine is used by people who are taking other medicines that can cause drowsiness, such as the following:
There may be an increased risk of side effects such as dry mouth, constipation, difficulty passing urine and blurred vision if this medicine is used by people taking other medicines that have anticholinergic effects, such as the following:
The following medicines may increase the blood level of doxepin and could increase the risk of its side effects:
If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets for angina, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.
There may be a sudden and marked increase in blood pressure and heart rate if adrenaline, noradrenaline or phenylephrine are given by injection to people using doxepin.
There are currently no other medicines available in the UK that contain doxepin for use on the skin to relieve itching.
Sinepin capsules are a form of doxepin that are taken by mouth to treat depression.